Đặc điểm mẫu máu cuống rốn thu thập tại Bệnh viện Phụ sản Hà Nội từ 2021 - 2023 31=Characteristics of collected umbilical cord blood samples at Hanoi Obstetrics and Gynecology Hospital from 2021

Đặc điểm mẫu máu cuống rốn thu thập tại Bệnh viện Phụ sản Hà Nội từ 2021 - 2023 31=Characteristics of collected umbilical cord blood samples at Hanoi Obstetrics and Gynecology Hospital from 2021 - 2023

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Tác giả: Văn Toán Đào, Bá Khanh Nguyễn, Hà Thanh Nguyễn, Mạnh Trí Nguyễn, Trọng Phúc Nguyễn, Văn Hoàng Nguyễn, Văn Long Nguyễn, Ngọc Quế Trần, Thị Nguyệt Trần, Thị Thu Huyền Trương, Thị Vân Thùy Tưởng

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.31-43

Bộ sưu tập: Metadata

ID: 244619

Thêm vào giỏ

Cord blood (CB) has become an extremely valuable source of stem cells for regenerative medicine. The collection of CB always bears a risk of low collected volume and microbiological contamination, which affects storage and future use. Therefore, this study was conducted to describe the characteristics of CBs and explore the relationship of maternal, neonatal and obstetric factors to CB collection results. Cross-sectional descriptive study on 434 CB samples collected at Hanoi Obstetrics and Gynecology Hospital from October 2021 to June 2023. All collected CB were with the private purpose. The ratio of boys/girls with CB collected was 1.6. The average volume of CB was 85.7 ± 27.2ml. Microbiological testing recorded that 1.8% of CB samples were positive (fungi, bacteria). The positive CB had a lower average volume than the negative group (69.3ml vs 86.2ml, p <
0.01). Factors associated with low collected CB volume include maternal systemic disease, lower birth weight (<
3000gram), younger gestational age (<
37 weeks), and female. Lower CB volume significantly increases the risk of CB contamination. Other factors such as maternal obstetric diseases, collector, and type of birth have not been found to be significant in predicting low collected CB volume or infection.Máu cuống rốn (MCR) là nguồn tế bào gốc giá trị cho y học tái tạo. Việc thu thập máu cuống rốn luôn có nguy cơ thể tích thấp và nhiễm nấm khuẩn, ảnh hưởng khả năng sử dụng sau này. Nghiên cứu được thực hiện nhằm mô tả đặc điểm mẫu máu cuống rốn được thu thập tại Bệnh viện Phụ sản Hà Nội. Nghiên cứu mô tả cắt ngang trên 434 mẫu máu cuống rốn thu thập theo yêu cầu từ tháng 10/2021 đến tháng 6/2023. Tỷ lệ sơ sinh trai/gái được thu thập máu cuống rốn là 1,6. Thể tích trung bình máu cuống rốn là 85,7 ± 27,2ml. Xét nghiệm vi sinh ghi nhận 8/434 chiếm 1,8% mẫu máu cuống rốn có tình trạng (+). Nhóm máu cuống rốn (+) có thể tích trung bình thấp hơn nhóm (-) (69,3ml và 86,2ml với p <
0,01). Các yếu tố có liên quan tới thể tích máu cuống rốn thu thập thấp bao gồm có bệnh lý toàn thân mẹ, trọng lượng thai <
3000g, tuổi thai <
37 tuần và giới tính thai là nữ. Thể tích máu cuống rốn thấp có ý nghĩa làm tăng nguy cơ máu cuống rốn bị nhiễm khuẩn. Các yếu tố về bệnh lý sản khoa, người thu thập, hình thức sinh chưa thấy liên quan với thể tích máu cuống rốn thu thập thấp hay mẫu nhiễm tác nhân gây bệnh.

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