Tình hình kháng kháng sinh của một số vi khuẩn gây nhiễm khuẩn huyết tại Bệnh viện E năm 2023=Prevalence of antimicrobial resistance of common bacteria isolated from blood cultures at E Hospital in 2023

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Tác giả: Hạ Long Hải Lê, Huy Hoàng Lê, Huyền My Lê, Văn Hưng Lê, Hoàng Việt Nguyễn, Thanh Bình Nguyễn, Thị Hà Vinh Nguyễn, Văn An Nguyễn, Quỳnh Hoa Phạm, Thị Vân Phạm, Văn Hậu Phan, Thị Thu Hiền Trương, Huy Lượng Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.118-128

Bộ sưu tập: Metadata

ID: 244633

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Bloodstream infections are severe infections that kill millions of people annually worldwide. This study aims to evaluate the prevalence and antimicrobial resistance of bacterial strains associated with bloodstream infection at E Hospital in 2023. Out of 2,094 blood culture samples, 275 bacterial strains were isolated, constituting a prevalence rate of 13.1%. The most common pathogens isolated were E. coli (29.1%), K. pneumoniae (18.5%), and S. aureus (13.5%). Notably, 58.1% of E. coli and 2.4% of K. pneumoniae were found to produce extended-spectrum beta-lactamase. Regarding antibiotic susceptibility, E. coli exhibited high sensitivity to imipenem (100%), meropenem (100%) and ertapenem (96.8%). For K. pneumoniae, the highest susceptibility was to amikacin (70.7%) and gentamicin (65.9%). For S. aureus, the highest resistance was to benzylpenicillin at 94.1%, while methicillin resistance was identified in 61.8% of cases. Importantly, no vancomycin-resistant strains were detected. The findings highlight the frequent occurrence of elevated resistance rates among E. coli, K. pneumoniae, and S. aureus to commonly prescribed antibiotics. Therefore, this study underscores the importance of rigorous infection control measures and judicious antibiotic usage to prevent the spread of antibiotic-resistant bacterial strains.Nhiễm khuẩn huyết là một nhiễm trùng nặng, mỗi năm gây tử vong cho hàng triệu người trên thế giới. Nghiên cứu này được tiến hành nhằm mục đích đánh giá tỷ lệ nhiễm và tính kháng kháng sinh của một số chủng vi khuẩn gây nhiễm khuẩn huyết tại Bệnh viện E năm 2023. Trong 2094 mẫu cấy máu, nghiên cứu đã phân lập được 275 chủng vi khuẩn, chiếm tỷ lệ 13,1%. Tác nhân gây bệnh hay gặp nhất là E. coli (29,1%), K. pneumoniae (18,5%) và S. aureus (13,5%). Tỷ lệ E. coli và K. pneumoniae sinh men betalactamase phổ rộng là 58,1% và 2,4%. E. coli nhạy cảm nhất với imipenem (100%), meropenem (100%) và ertapenem (96.8%). Trong khi đó, K. pneumoniae nhạy cảm cao nhất với amikacin (70,7%) và gentamycin (65,9%). Tỷ lệ S. aureus kháng methicillin là 61,8%, đề kháng cao nhất với benzylpenicillin (94,1%) và chưa phát hiện chủng đề kháng vancomycin. Nghiên cứu chỉ ra tầm quan trọng của việc kiểm soát nhiễm khuẩn và sử dụng kháng sinh hợp lý để giảm thiểu sự lây lan của các chủng vi khuẩn kháng kháng sinh.

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