Tác dụng hạ glucose máu của cao chiết lá ổi trên chuột nhắt trắng bị đái tháo đường tuýp 2=A study on the hypoglycemic action of guava leaf extract in type 2 diabetes mice

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Hồng Khánh Đỗ, Anh Tuấn Lê, Thị Thuý Mậu Nguyễn, Hồng Minh Phan, Tiến Đạt Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.153-162

Bộ sưu tập: Metadata

ID: 244635

Thêm vào giỏ

Nghiên cứu được tiến hành nhằm đánh giá tác dụng hạ glucose máu của cao chiết lá ổi trên chuột nhắt trắng chủng Swiss bị đái tháo đường týp 2 gây ra bởi chế độ ăn giàu chất béo kết hợp với streptozocin (STZ). Nghiên cứu trải qua hai giai đoạn: Giai đoạn 1 gây mô hình đái tháo đường dạng týp 2 trên chuột nhắt trắng bằng chế độ ăn giàu chất béo liên tục trong 8 tuần kết hợp với tiêm STZ liều 100 mg/kg
Giai đoạn 2, chuột được uống cao chiết lá ổi ở 2 mức liều 100 mg/kg/ngày và 300 mg/kg/ngày trong vòng 2 tuần. Số liệu thu được cho thấy cao chiết lá ổi ở cả mức liều nghiên cứu đều làm giảm nồng độ glucose máu, xu hướng làm giảm các nồng độ TC, TG, LDL-C đồng thời với tăng HDL-C, kèm theo sự cải thiện mức độ tổn thương gan và tuỵ trên hình ảnh vi thể. Cao chiết lá ổi liều 300 mg/kg thể hiện hiệu quả hạ đường huyết mạnh hơn liều 100 mg/kg. Kết quả nghiên cứu này đã chỉ ra tác dụng hạ glucose máu của cao chiết lá ổi, và tác dụng này được thể hiện theo cách phụ thuộc liều.The purpose of this study was to investigate the hypoglycemic action of guava leaf extract on the mouse model with type 2 diabetes caused by a high-fat diet plus streptozotocin. This research was conducted of two stages: In the first stage, diabetes mellitus type 2 condition was induced in Swiss mice by a highfat diet and streptozotocin for eight weeks
in the second stage, guava leaf extract was administered orally to mice at low (100 mg/kg) and high (300 mg/kg) doses for 2 weeks. The obtained data show that guava leaf extract at both studied doses reduced blood glucose concentrations, with a tendency to reduce TC, TG, and LDL-C concentrations simultaneously with increasing HDL-C, accompanied by an improvement in the degree of liver and pancreas damage on microscopic examination. Guava leaf extract at the 300 mg/kg exhibited a more potent hypoglycemic effect than 100 mg/kg. The above results suggest guava left extract has a blood glucose-lowering effect which was dose-dependent.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR