Đánh giá tác dụng kích thích mọc tóc của cao chiết cỏ nhọ nồi trên động vật thực nghiệm=Hair growth stimulation effect of Elipta prostarta (L.) extract on experimental animals

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Tác giả: Thị Mỹ Hằng Bùi, Thị Hồng Khánh Đỗ, Mỹ Dung Hồ, Phương Thanh Mai, Thái Hà Dương Nguyễn, Hồng Minh Phan, Thị Hồng Ngọc Trần, Tiến Đạt Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.163-172

Bộ sưu tập: Metadata

ID: 244636

Thêm vào giỏ

Nghiên cứu được tiến hành nhằm đánh giá tác dụng kích thích mọc tóc của cao chiết cỏ nhọ nồi (CCCNN) trên động vật thực nghiệm. Chuột cống trắng chủng Wistar được cạo lông và tiêm màng bụng cyclophosphamid liều 150 mg/kg để gây mô hình ức chế mọc lông. Chuột cống trắng được chia ngẫu nhiên thành 5 lô gồm lô chứng sinh học, lô mô hình, lô chứng dương (uống finasterid), các lô uống cao chiết cỏ nhọ nồi liều 50 mg/kg và 150 mg/kg. Các chỉ tiêu đánh giá bao gồm mức độ rụng lông và chiều dài sợi lông sau ngày 19, ngày 26 và hình ảnh đại thể, vi thể vùng cạo lông. Kết quả cho thấy cao chiết cỏ nhọ nồi liều 50 mg/kg và 150 mg/kg có tác dụng kích thích mọc lông, tăng chiều dài sợi lông và phát triển nang lông đáng kể so với lô mô hình. Như vậy, cao chiết cỏ nhọ nồi có tác dụng kích thích mọc lông trên chuột cống trắng được gây mô hình rụng lông bằng cylophosphamid.The purpose of this study was to evaluate the hair growth-stimulating effect of Eclip prostrata extract (CCCNN) on experimental animals. Wistar rats were shaved and given a cyclophosphamide peritoneal injection of 150 mg/kg to induce a pattern of hair growth inhibition. Wistar rats were randomly divided into 5 groups: biological control group, model group, positive control group (finasteride), 50 mg/kg dose and 150 mg/kg dose of CCCNN. Evaluation criteria include the level of hair loss, hair length after 19 days, 26 days and macroscopic, microscopic images of the shaved area. The results showed that 50 and 150 mg/kg doses of Eclip prostrata extract have the effect of stimulating hair growth and significantly increasing hair length as well as improving microscopic hair follicle growth. Based on the experimental results, we suggest that Eclip prostrata extract has a stimulating effect on hair growth on the cylophosphamide- induced model on rats.

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