Tác dụng của viên khôi tím Bavieco trên động vật thực nghiệm gây loét tá tràng bằng Cysteamin=Effects of Khoi tim Bavieco capsules on Cysteamine - induced duodenal ulcers in experimental animals

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Tác giả: Thùy Dương Đậu, Thị Thúy Nguyễn, Quốc Sự Phạm, Thị Vân Anh Phạm, Lê Hồng Tô

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.172-181

Bộ sưu tập: Metadata

ID: 244647

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Duodenal ulcer is a common disease of the digestive tract. This study was conducted to evaluate the effects of Khoi tim Baiveco capsules on cystemine-induced duodenal ulcer model in Wistar white rats. Rats were divided into 5 groups, the control group and the model group were given distilled water, the remaining groups were given famotidine 50 mg/kg
Khoi tim Bavieco capsules 0.48 capsules/ kg and 1.44 capsules/kg for 10 consecutive days, respectively. Then, rats of groups 2 to 5 duodenal ulcers were iduced by oral cysteamine at the dose of 400 mg/kg twice. Evaluation indicators include duodenal ulcer index, % ulcer inhibition, macroscopic and microscopic images of the duodenum. Research results showed that Khoi tim Bavieco capsules reduced the duodenal ulcer index, had the effect of inhibiting ulcers and improving pathological lesions compared to the model group. Thus, Khoi tim Bavieco capsules had anti-ulcer effects on cysteamine-induced duodenal ulcer rats.Loét tá tràng là bệnh lý thường gặp của đường tiêu hóa. Nghiên cứu này được thực hiện nhằm đánh giá tác dụng của viên Khôi tím Bavieco trên mô hình gây loét tá tràng ở chuột cống trắng chủng Wistar. Chuột được chia thành 5 lô: lô chứng và lô mô hình uống nước cất, các lô còn lại uống famotidin 50 mg/ kg
viên Khôi tím Bavieco 0,48 viên/kg và 1,44 viên/kg trong 10 ngày liên tục. Sau đó, chuột lô 2 đến 5 được gây loét tá tràng bằng cysteamin 400 mg/kg uống 2 lần. Các chỉ số đánh giá bao gồm chỉ số loét, % ức chế loét, hình ảnh đại thể, vi thể tá tràng. Kết quả nghiên cứu cho thấy viên Khôi tím Bavieco giảm chỉ số loét, có tác dụng ức chế loét và cải thiện tổn thương trên giải phẫu bệnh so với lô mô hình. Như vậy, viên Khôi tím Bavieco có tác dụng chống loét trên chuột cống trắng gây loét tá tràng bằng cysteamin.

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