Độc tính cấp và bán trường diễn của bộ sản phẩm thực phẩm chức năng ageLOC TR90 trên thực nghiệm=Acute and sub-chronic toxicity of ageLOC TR90 functional foods in experiments

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Thanh Tú Nguyễn, Minh Hoàn Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.183-192

Bộ sưu tập: Metadata

ID: 244652

Thêm vào giỏ

Nghiên cứu nhằm xác định độc tính cấp và độc tính bán trường diễn của bộ sản phẩm thực phẩm chức năng ageLOC TR90 trên thực nghiệm. Nghiên cứu độc tính cấp trên chuột nhắt chủng Swiss bằng phương pháp Litchfield - Wilcoxon. Nghiên cứu độc tính bán trường diễn trên chuột cống trắng chủng Wistar theo hướng dẫn của WHO. Kết quả nghiên cứu cho thấy với liều cao nhất chuột có thể dung nạp được (liều 50,0 g/kg thể trọng chuột - gấp 2,89 lần liều dùng dự kiến trên người) không xác định được liều gây chết 50% số động vật thí nghiệm (LD50). Bộ sản phẩm thực phẩm chức năng ageLOC TR90 không gây độc tính bán trường diễn trên chuột cống trắng với liều 8,38 g/kg thể trọng chuột/ngày (liều tương đương liều lâm sàng) và liều 25,14 g/kg thể trọng chuột/ngày (liều gấp 3 liều lâm sàng) trong 90 ngày liên tục uống thuốc. Tất cả các chỉ số theo dõi về tình trạng chung, cân nặng, chức năng tạo máu, chức năng gan, chức năng thận đều nằm trong giới hạn bình thường, mô bệnh học gan, thận không có sự khác biệt so với lô chứng.This study aimed to evaluate the acute and sub-chronic toxicity of ageLOC TR90 functional foods in the experimental animals. The acute toxicity was performed in Swiss mice based on the Litchfield - Wilcoxon method. The sub-chronic toxicity was evaluated in Wistar rats according to the World Health Organization's guidance. The results showed that the highest dose of ageLOC TR90 dietary supplement (50.0 g/kg b.w./day, 2.89 times as high as the maximal recommended human dose) did not show acute oral toxicity in mice and the median lethal dose (LD50) was not determined. Administration of ageLOC TR90 at 8.38 g/kg b.w./day (equivalent to clinical dose) and 25.14 g/kg body weight (three times as high as the clinical dose) in 90 days did not produce any significant detrimental effect on the body weight, hematological and biochemical parameters, as well as gross and microscopic images of the rats’ liver and kidney, compared to control group.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR