Tác dụng của viên nang cứng từ bài thuốc “Dạ dày hđ” trên bệnh nhân viêm loét dạ dày tá tràng có Helicobacter pylori dương tính=The effect of hard capsule from the herbal medicine “Da day HD” on patients with helicobacter pylori

Tác dụng của viên nang cứng từ bài thuốc “Dạ dày hđ” trên bệnh nhân viêm loét dạ dày tá tràng có Helicobacter pylori dương tính=The effect of hard capsule from the herbal medicine “Da day HD” on patients with helicobacter pylori - Positive gastric and duodenal ulcer

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Tác giả: Hồng Quân Dương, Thị Thanh Hường Nghiêm, Thị Thanh Tú Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.250-258

Bộ sưu tập: Metadata

ID: 244681

Thêm vào giỏ

Nghiên cứu được thực hiện nhằm đánh giá tác dụng điều trị bệnh viêm loét dạ dày tá tràng có Helicobacter pylori dương tính bằng viên nang cứng từ bài thuốc “Dạ dày HĐ” và theo dõi tác dụng không mong muốn của chế phẩm trên lâm sàng và cận lâm sàng. Nghiên cứu can thiệp lâm sàng mở, so sánh trước sau điều trị trên 72 bệnh nhân được chẩn đoán viêm loét dạ dày - tá tràng có Helicobacter pylori dương tính. Bệnh nhân được uống viên nang cứng từ bài thuốc “Dạ dày HĐ”, hàm lượng 500 mg/1 viên, 8 viên/ngày, uống liên tục trong 45 ngày. Kết quả nghiên cứu cho thấy viên nang cứng từ bài thuốc “Dạ dày HĐ” có tác dụng cải thiện các triệu chứng lâm sàng có ý nghĩa thống kê so với trước điều trị như đau tức thượng vị, ăn kém, chán ăn, nôn, buồn nôn, ợ hơi, ợ chua, đầy bụng chậm tiêu (p <
0,05). Mức độ nhiễm Helicobacter pylori trên kết quả mô bệnh học giảm có ý nghĩa thống kê so với trước điều trị (p <
0,05). Tỷ lệ Helicobacter pylori âm tính là 57,8%. Có 5,6% bệnh nhân bị táo bón sau khi sử dụng thuốc. Chưa phát hiện tác dụng không mong muốn của chế phẩm trên cận lâm sàng.This study aimed to evaluate the effects of herbal medicine “Da day HD” on patients with Helicobacter pylori - positive gastric and duodenal ulcers and to survey the adverse effect of the tablets in clinical and paraclinical. An open-label clinical intervention study was carried out, comparing pre- and post-treatment outcomes in 72 patients diagnosed with gastric and duodenal ulcers positive for Helicobacter pylori. Patients were administered “Da day HD” tablets at 500mg per tablet, 8 tablets per day, continuously for 45 days. The results of the study showed that “Da day HD” significantly improved clinical symptoms compared to pretreatment, such as epigastric pain, poor appetite, aversion to food, nausea, vomiting, belching, acid regurgitation, and delayed gastric emptying (p <
0.05). The degree of Helicobacter pylori infection assessed histologically significantly decreased compared to pre-treatment (p <
0.05). The negative rate of Helicobacter pylori was 57.8%. Constipation occurred in 5.6% of patients after medication use. No adverse effect of the herbal medicine were detected in paraclinical.

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