Đánh giá kết quả hoá xạ trị đồng thời bằng kỹ thuật điều biến liều thể tích hình cung trên bệnh nhân ung thư thực quản 1/3 giữa dưới=Evaluating the results of concurrent chemoradiotherapy using VMAT technique for lower middle esophageal cancer

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thanh Tùng Nguyễn, Văn Hiếu Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.207-217

Bộ sưu tập: Metadata

ID: 244727

Thêm vào giỏ

Nghiên cứu mô tả hồi cứu kết hợp tiến cứu trên 78 bệnh nhân ung thư biểu mô thực quản 1/3 giữadưới giai đoạn II-IVA được điều trị hóa xạ đồng thời bằng kỹ thuật VMAT tại Bệnh viện K từ 1/2022 đến 12/2023 nhằm mô tả một số đặc điểm lâm sàng và cận lâm sàng, đánh giá đáp ứng điều trị, thông số về liều và các độc tính của phác đồ này. Tuổi trung bình 56,5 ± 5,9, phần lớn ở giai đoạn III. Tỷ lệ đáp ứng toàn bộ sau hóa xạ trị là 34,2%. Các thông số về D2, D98 và độ bao phủ liều V95 (93,96 - 98,20%) cũng như quá liều V105% (4,7 - 10,2%) của kỹ thuật VMAT là tốt. Liều tại các cơ quan nguy cấp đều thấp hơn mức được khuyến cáo. 26 bệnh nhân phẫu thuật sau hóa xạ trị,100% đạt diện cắt R0 là. Đáp ứng về mô bệnh học sau mổ tốt. Độc tính trên hệ huyết học, viêm phổi và viêm da đều ở mức độ nhẹ, không có biến chứng về tim mạch. Phác đồ hóa xạ trị đồng thời bằng kỹ thuật VMAT cho thấy kết quả tốt và độc tính là nhẹ.The study describes the outcomes of concurrent chemoradiotherapy using VMAT technique in 78 patients with squamous cell carcinoma of the mid-to-lower esophagus, stage II-IVA, treated at Vietnam National cancer hospital from January 2022 to December 2023. The aim was to depict clinical and paraclinical characteristics, assess treatment response, dose parameters, and toxicity of this protocol. The average age was 56.5 ± 5.9 years, with the majority in stage III. The overall response rate after radiotherapy was 34.2%. Dosimetric parameters such as D2, D98, and V95 dose coverage (93.96 - 98.20%) as well as V105% overdose (4.7 - 10.2%) of the VMAT technique were greater than other methods. Doses to ORAS were below recommended levels. 26 patients underwent surgery after radiotherapy, with 100% achieving R0 resection. Histopathological response post-surgery showed a better result comparing to other methods. Hematological, pulmonary, and dermatological toxicities were mild, with no cardiac complication. Concurrent chemoradiotherapy using VMAT technique demonstrated good outcomes and mild toxicity.

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