Nồng độ huyết thanh Interleukin-15 trong hội chứng Stevens-Johnson/ hoại tử thượng bì nhiễm độc=Measuring serum concentrations of Interleukin-15 in patients with Stevens-Johnson syndrome/ toxic epidermal necrolysis

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Tác giả: Huyền My Lê, Thị Huyền Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.129-136

Bộ sưu tập: Metadata

ID: 244742

Thêm vào giỏ

Hội chứng Stevens-Johnson (SJS) và hoại tử thượng bì nhiễm độc (TEN) là những phản ứng nặng, thường do thuốc, có biểu hiện ở da, niêm mạc. Một số yếu tố về gen và miễn dịch được cho là có liên quan tới SJS/ TEN, trong đó có interleukin-15. Trong nghiên cứu này, kỹ thuật hấp phụ miễn dịch vi hạt đánh dấu huỳnh quang (fluorescence covalent microbead immunosorbent assay, ProcartaPlex Immunoassay Panels kit, Thermo Fisher Scientific, USA) được sử dụng để xác định nồng độ interleukin-15 trong huyết thanh của các bệnh nhân SJS/TEN và phân tích mối tương quan của nó với mức độ bệnh. Sử dụng Mann-Whitney U test để so sánh nồng độ huyết thanh interleukin-15 của hai nhóm, Spearman rank correlation test để đánh giá sự tương quan. Sự khác biệt có ý nghĩa thống kê khi p-value <
0,05. Kết quả có 61 bệnh nhân (29 nam, 32 nữ
21 bệnh nhân SJS và 40 bệnh nhân TEN), trung vị tuổi là 51 (khoảng tứ phân vị: 37 - 58) tuổi và 20 người khỏe mạnh tham gia nghiên cứu. Trung vị diện tích thương tổn da là 45% diện tích cơ thể (khoảng tứ phân vị: 8 - 70%). Điểm SCORTEN có trung vị là 2 (khoảng tứ phân vị: 1 - 2). Nồng độ interleukin-15 huyết thanh ở nhóm SJS/TEN có trung vị là 2,61 pg/ml (khoảng tứ phân vị: 1,49 - 4,04 pg/ml), ở nhóm TEN có trung vị là 2,61 pg/ml (khoảng tứ phân vị: 1,49 - 3,73 pg/ml), không cao hơn so với nhóm khỏe mạnh. Có mối liên quan giữa nồng độ interleukin-15 huyết thanh với điểm SCORTEN ở nhóm bệnh nhân SJS.Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions, with immunological and genetic factors, including interleukin-15 (IL- 15), implicated in their pathogenesis. In this cross-sectional descriptive study, serum IL-15 levels were measured by using the fluorescence covalent microbead immunosorbent assay (ProcartaPlex Immunoassay Panels kit, Thermo Fisher Scientific, USA) and its correlation with the disease severity was ana lyzed. The Mann-Whitney U test was used to compare mean and median values between groups, while the Spearman rank correlation test assessed correlations, with statistical significance considered at p-value <
0.05. A total of 61 patients (29 males and 32 females
21 SJS patients and 40 TEN patients) with a median age of 51 years (interquartile range: 37 - 58) and 20 healthy controls were included in this study. The median lesional area was 45% of the body surface area (interquartile range: 8 - 70%). The median SCORTEN score was 2 (interquartile range: 1 - 2). The median serum concentration of IL-15 in SJS/TEN patients was 2.61 pg/ml (interquartile range: 1.49 - 4.04 pg/ml) and 2.61 pg/ml (interquartile range: 1.49 - 3.73 pg/ml) in TEN patients, not statistically higher than in the healthy control group. A correlation was observed between serum concentrations of IL-15 and the SCORTEN score in TEN patients.

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