Tình trạng di căn hạch nách và đặc điểm hóa mô miễn dịch ung thư vú thể vi nhú xâm nhập được phẫu thuật tại Bệnh viện K=Lymph node metastasis status and immunohistochemistry characteristics of invasive micropapillary breast cancer patients undergoing surgery at K Hospital

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hồng Khoa Phạm, Nguyên Tuấn Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.166-175

Bộ sưu tập: Metadata

ID: 244745

Thêm vào giỏ

Nghiên cứu đánh giá tình trạng di căn hạch nách và đặc điểm hoá mô miễn dịch của 62 bệnh nhân ung thư vú thể vi nhú xâm nhập được phẫu thuật tại Bệnh viện K từ tháng 1/2018 đến tháng 12/2023. Độ tuổi trung bình của bệnh nhân trong nghiên cứu là 50,1 tuổi. Hầu hết bệnh nhân có kết quả trên siêu âm là BIRADS 4C và BIRADS 5 lần lượt là 37,1% và 46,8%. Bệnh nhân trong nghiên cứu có tỷ lệ di căn hạch nách là 72,6%, trong đó giai đoạn N1, N2 và N3 lần lượt là 40,3%
22,6% và 9,7%. Tỷ lệ bệnh nhân có ER dương tính, PR dương tính, HER2/neu (+++) lần lượt là 87,1%
74,2% và 29%. Bệnh nhân có tình trạng xâm nhập mạch bạch huyết chiếm tỷ lệ cao 56,5%. Các yếu tố có liên quan đến tình trạng di căn hạch nách bao gồm kích thước u, tình trạng xâm nhập mạch bạch huyết và thành phần vi nhú của khối u. Trong khi đó không có sự khác biệt về tỷ lệ di căn hạch nách giữa các nhóm phân tử. Ung thư vú thể vi nhú xâm nhập có những đặc điểm thể hiện mức độ ác tính cao, tình trạng di căn hạch nách thường xảy ra sớm và tỷ lệ dương tính với thụ thể nội tiết cao trong khi đó tỷ lệ bộc lộ HER2/neu thấp.The study evaluates the status of axillary lymph node metastasis and immunohistochemical characteristics of 62 patients with invasive micropapillary breast cancer who underwent surgery at K Hospital from January 2018 to December 2023. The average age was 50.1 years. Most patients had BIRADS 4C or BIRADS 5 on breast ultrasound (37.1% and 46.8%, respectively). The rate of axillary lymph node metastasis was 72.6%, with stages N1, N2, and N3 being 40.3%, 22.6%, and 9.7%, respectively. The rates of ER-positive, PR-positive, and HER2/neu (+++) patients were 87.1%, 74.2%, and 29%, respectively. Patients with lymphovascular invasion accounted for a high proportion at 56.5%. Factors related to axillary lymph node metastasis included tumor size, lymphovascular invasion, and the micropapillary component of the tumor. However, there was no difference in the rate of axillary lymph node metastasis among pathologic subtypes. Invasive micropapillary breast cancer exhibits characteristics of high malignancy, with early axillary lymph node metastasis and a high rate of positive hormone receptor and low rate of HER2/neu overexpression.

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