Đánh giá mối tương quan giữa lắng đọng mỡ tuyến tụy trên cắt lớp vi tính với chỉ số khối cơ thể và đái tháo đường tuýp 2=Correlation between pancreatic fat deposition by computed tomography with BMI and type 2 diabetes mellitus

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Tác giả: Trung Thành Đinh, Đức Linh Đỗ, Thị Giang Đoàn, Hồng Đức Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.213-222

Bộ sưu tập: Metadata

ID: 244754

Thêm vào giỏ

Nghiên cứu nhằm mục đích xác định các mức độ lắng đọng mỡ trong tụy (IPFD) trên cắt lớp vi tính ở người bình thường và đánh giá mối tương quan với các chỉ số khối cơ thể (BMI) và đái tháo đường tuýp 2. Các chỉ số này nhằm xác định IPFD qua quan sát (chia làm 4 độ 0, 1, 2, 3) và đo tỷ trọng xác định trên cắt lớp vi tính. Tổng có 208 người độ tuổi 47,6 ± 14,8 được chụp cắt lớp vi tính ổ bụng và xác định là không có bệnh lý viêm hoặc u tụy. Kết quả cho thấy: độ 0, 1, 2 chiếm tỷ lệ ở vùng đầu tụy và đuôi tụy lần lượt là: 86,5%, 12% và 1,4%
và 86,1%, 13%, và 1,0%, không có trường hợp nào lắng đọng mỡ độ 3. Tuổi ở người có lắng đọng mỡ độ 1 cao hơn so với độ 0 (p <
0,05). Giá trị trung bình của BMI tăng dần theo độ nhiễm mỡ tụy từ độ 0 đến độ 2 (p <
0,05)
Tỷ trọng tụy thấp hơn ở người thiếu cân và béo phì so với BMI bình thường (p <
0,05). Có sự phù hợp giữa mức độ phân độ tụy trên quan sát và đo tỷ trọng tụy. Bệnh nhân mắc đái tháo đường tuýp 2 có tỷ trọng trung bình của tụy thấp hơn và mức độ IPFD cao hơn so với không bị bệnh này tương ứng 47,8 ± 4,7 HU và 44,9 ± 7,6 HU (p <
0,003).The study aimed to determine the grade of intra-pancreatic fat deposition (IPFD) on computed tomography (CT) in normal people and evaluate the correlation with body mass index (BMI) and type 2 diabetes mellitus (T2DM). These indicators are intended to determine the grade of pancreatic fat deposition through observation (divided into 4 grade 0, 1, 2 and 3) and measuring HU determined on CT. A total of 208 people aged 47.6 ± 14.8 years old had abdominal CT scans and were determined not to be related to pancreatic inflammation or tumor. The results showed that grade 0,1 and 2 of the pancreatic head and tail accounted for 86.5%, 12% and 1.4% respectively
and 86.1%, 13%, and 1.0% respectively. There were no cases of grade 3 fat deposition. Age in people with grade 1 fat deposition was higher than that of grade 0 (p <
0.05). The average value of BMI gradually increases with the grade of IPFD from grade 0 to grade 2 (p <
0.05)
Pancreatic density in underweight and obese people is lower than normal BMI (p <
0.05). There is agreement between the pancreatic grades in terms of observation and measurement of pancreatic density. Patients with T2DM had lower mean pancreatic density and higher grade of IPFD than those without this disease, 47.8 ± 4.7HU and 44.9 ± 7.6HU, respectively (p <
0.003).

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