Mối liên quan giữa điểm CONUT và kết quả lâm sàng ở bệnh nhân đa u tuỷ xương=Association between controlling nutritional status score and clinical outcomes in patients with multiple myeloma

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Tác giả: Thị Phương Liên Đinh, Văn Quang Hà, Văn Bằng Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.67-78

Bộ sưu tập: Metadata

ID: 244778

Thêm vào giỏ

This study was conducted to determine the relationship between CONUT score and clinical outcomes in patients receiving treatment at Military Hospital 103 for multiple myeloma. A case control study was conducted on 61 patients treated for multiple myeloma at Military Hospital 103 from January 2014 to June 2024. 85.7% of patients in the CONUT ≤ 4 group had disease control compared to 73.1% of patients who had disease control in the CONUT >
4 group, with p = 0.038. Patients in the CONUT >
4 group were 2,779 times more at risk of passing than those in the CONUT ≤ 4 group. Progressions-free survival (PFS) and overall survival (OS) of the CONUT >
4 group were 11.9 months and 19.6 months, respectively, which were statistically significantly shorter compared to PFS (30.5 months) and (OS = 63.7 months) of the CONUT ≤ 4 group, with values of p = 0.041 and p = 0.002, respectively. With p = 0.018, the CONUT score's sensitivity, specificity, and AUC for predicting OS were 59.4%, 75.9%, and 0.677, respectively. CONUT score is a factor that could predict the effectiveness of treatment response and OS in patients with multiple myeloma.Xác định mối liên quan giữa điểm CONUT với kết quả lâm sàng ở bệnh nhân đa u tủy xương điều trị tại Bệnh viện Quân y 103. Nghiên cứu bệnh - chứng trên 61 bệnh nhân đa u tủy xương được điều trị tại Bệnh viện Quân y 103 từ tháng 01/2014 đến tháng 06/2024. 85,7% bệnh nhân kiểm soát được bệnh ở nhóm CONUT ≤ 4 so với 73,1% bệnh nhân kiểm soát được bệnh ở nhóm CONUT >
4, với p = 0,038. Bệnh nhân ở nhóm CONUT >
4 có nguy cơ tử vong cao hơn 2,779 lần so với bệnh nhân ở nhóm CONUT ≤ 4. PFS và OS của nhóm CONUT >
4 lần lượt là 11,9 tháng và 19,6 tháng ngắn hơn có ý nghĩa thống kê so với PFS (30,5 tháng) và (OS = 63,7 tháng) của nhóm CONUT ≤ 4, với các giá trị lần lượt là p = 0,041 và p = 0,002. Độ nhạy, độ đặc hiệu và AUC của điểm CONUT trong dự báo OS lần lượt là 59,4%
75,9% và 0,677, với p = 0,018. Điểm CONUT là một yếu tố có thể dự báo về hiệu quả đáp ứng điều trị và OS ở bệnh nhân đa u tủy xương.

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