Đặc điểm lâm sàng, cận lâm sàng và mối liên quan với nồng độ EBV-DNA huyết thanh ở bệnh nhân ung thư vòm mũi họng giai đoạn III - IVA tại Bệnh viện K=Clinical, subclinical characteristics and relationship of serum EBV-DNA levels in patients with stages III-IVA nasopharyngeal carcinoma at National Cancer Hospital

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Tác giả: Văn Đăng Nguyễn, Văn Thắng Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.62-71

Bộ sưu tập: Metadata

ID: 244797

Thêm vào giỏ

Nasopharyngeal carcinoma is a common cancer in the head and neck area. The disease has a very clear geographical factor and is closely related to the Epstein Barr virus. A crosssectional study was performed on 118 patients with stage III-IVA nasopharyngeal cancer from June 2023 to June 2024 at the Vietnam national cancer hospital to describe various clinical and subclinicalcharacteristics and the relationship with serum EBV-DNA. The appearance of neck lymph node is the most common symptom, accounting for 61.8%. On magnetic resonance imaging, invasion of the skull base, cervical spine, and paranasal cavity accounts for the highest rate at 59.3%. T3 tumors are the most common with 34.7%
N2 lymph node metastasis is the most common with 56.8%. Stages III and IVA are 57.6% and 42.4%, respectively. 91% of patients had positive serum EBV-DNA quantification. EBV-DNA concentration gradually increased with disease stage, which was significantly related to the level of lymph node metastasis N (p <
0.05).Ung thư vòm mũi họng là bệnh ung thư thường gặp vùng đầu cổ. Bệnh có yếu tố địa lý rất rõ rệt và liên quan chặt chẽ với virus Epstein Barr. Nghiên cứu cắt ngang trên 118 người bệnh ung thư vòm mũi họng giai đoạn III - IVA từ tháng 06/2023 đến tháng 06/2024 tại Bệnh viện K nhằm mô tả một số đặc điểm lâm sàng, cận lâm sàng và mối liên quan nồng độ EBV-DNA huyết thanh. Xuất hiện hạch cổ là triệu chứng hay gặp nhất, chiếm 61,8%. Trên cộng hưởng từ, xâm lấn nền sọ, cột sống cổ, khoang cạnh mũi chiếm tỉ lệ cao nhất với 59,3%. Khối u T3 hay gặp nhất với 34,7%
di căn hạch N2 hay gặp nhất với 56,8%. Tỉ lệ giai đoạn III, IVA lần lượt là 57,6% và 42,4%. Có 91% bệnh nhân định lượng EBV-DNA huyết thanh dương tính. Nồng độ EBV-DNA ở nhóm bệnh nhân giai đoạn IVA cao hơn giai đoạn III, trong đó liên quan có ý nghĩa với mức độ di căn hạch N (p <
0,05).

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