Huyết thanh chẩn đoán Mycoplasma pneumoniae ở các bệnh nhân hồng ban đa dạng, hội chứng Stevens-Johnson và hoại tử thượng bì nhiễm độc=Serological diagnosis of Mycoplasma pneumoniae in patients with erythema multiform, Stevens-Johnson syndrome, and toxic epidermal necrolysis

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Tác giả: Hữu Doanh Lê, Huyền My Lê, Thị Hà Vinh Nguyễn, Thị Thanh Thùy Nguyễn, Thị Minh Phương Phạm, Thị Hà Giang Quách, Thị Huyền Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.80-89

Bộ sưu tập: Báo, Tạp chí

ID: 244799

Thêm vào giỏ

Mycoplasma pneumoniae (M. pneumoniae) không chỉ gây bệnh ở phổi mà còn gây các biểu hiện ở da-niêm mạc. Nghiên cứu mô tả cắt ngang này được tiến hành trên 54 bệnh nhân hồng ban đa dạng (erythema multiforme- EM), 30 bệnh nhân hội chứng Steven-Johnson (Stevens-Jonhson syndrome-SJS)/hoại tử thượng bì nhiễm độc (toxic epidermal necrolysis-TEN) và 30 người khỏe mạnh nhằm xác định tỷ lệ huyết thanh dương tính với M. pneumoniae và mối liên quan của vi khuẩn này với đặc điểm lâm sàng. Kết quả cho thấy, tỷ lệ huyết thanh dương tính với IgG và IgM M. pneumoniae của nhóm SJS/TEN lần lượt là 13,33% và 33,33%
của nhóm EM là 20,37% và 25,93%
của nhóm khỏe mạnh là 10% và 16,67%. Sự khác biệt giữa các nhóm không có ý nghĩa thống kê. Trong nhóm SJS/TEN, tỷ lệ IgM M. pneumoniae dương tính ở nhóm <
50 tuổi là 53,33%, cao hơn so với nhóm ≥ 50 tuổi, p <
0,05
trong nhóm EM, tỷ lệ IgM M. pneumoniae dương tính ở nhóm <
30 tuổi là 40%, cao hơn so với nhóm ≥ 30 tuổi, p <
0,05
trong nhóm khỏe mạnh, không có sự khác biệt theo tuổi. Trong nhóm EM, tỷ lệ huyết thanh IgM M. pneumoniae dương tính của nhóm có sốt là 77,78%
của nhóm không có sốt là 15,56%, sự khác biệt có ý nghĩa thống kê với p = 0,0005
không có sự khác biệt giữa nhóm có thương tổn niêm mạc với nhóm không có.Mycoplasma pneumoniae causes not only pulmonary disease but also mucocutaneous manifestations. This cross-sectional descriptive study was conducted on 54 patients with erythema multiform (EM), 30 patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and 30 healthy controls, aiming to determine the seropositivity rates for M. pneumoniae and to examine the association between M. pneumoniae with clinical features in these groups. The findings revealed that IgG and IgM seropositivity rates for M. pneumoniae in the SJS/TEN group were 13.33% and 33.33%, respectively
in the EM group, 20.37% and 25.93%
and in the healthy group, 10% and 16.67%. These differences were not statistically significant. In the SJS/TEN group, the IgM seropositivity rate for M. pneumoniae in individuals under 50 was 53.33%, higher than in those aged 50 or older (p <
0.05). In the EM group, the IgM seropositivity rate in patients younger than 30 was 40%, higher than in those aged 30 or older (p <
0.05). No age-related difference was observed in the healthy group. Among the EM patients, the IgM seropositivity rate for M. pneumoniae in febrile patients was 77.78%, significantly higher than the afebrile patients (15.56%, p = 0.0005). There was no significant difference between patients with and without mucosal involvement.

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