Nghiên cứu tác dụng giảm ho của dung dịch xịt họng YHN trên thực nghiệm=Evaluation of antitussive effects of YHN throat spray solution in experimental animals

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Tác giả: Thế Ngọc Dương, Thu Phương Lương, Thanh Bình Nguyễn, Thị Thanh Loan Nguyễn, Huy Tần Phạm, Thanh Tùng Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Nghiên cứu y học (Đại học Y Hà Nội), 2024

Mô tả vật lý: tr.363-370

Bộ sưu tập: Metadata

ID: 244805

Thêm vào giỏ

Nghiên cứu được thực hiện nhằm đánh giá tác dụng giảm ho của dung dịch xịt họng YHN trên chuột nhắt trắng chủng Swiss gây ho bằng dung dịch amoniac. Chuột nhắt trắng được gây ho bằng dung dịch amoniac 25% liều 0,5 ml/chuột. Thời gian tiềm tàng ho, số cơn ho trong mỗi một phút cho đến hết phút thứ 5 và phần trăm ức chế số cơn ho được đánh giá. Kết quả nghiên cứu cho thấy dung dịch xịt họng YHN xịt 100 μl/ lần, 1 lần/ngày và xịt 100 μl/lần, 2 lần/ngày có tác dụng làm kéo dài thời gian tiềm tàng xuất hiện cơn ho và làm giảm có ý nghĩa thống kê số cơn ho so với lô mô hình. Khả năng ức chế cơn ho của dung dịch xịt họng YHN xịt 100 μl/lần, 1 lần/ngày và xịt 100 μl/lần, 2 lần/ngày tương ứng là 33,22% và 41,96%. Như vậy, dung dịch xịt họng YHN có tác dụng giảm ho trên mô hình gây ho bằng amoniac ở chuột nhắt trắng chủng Swiss.The study aimed to evaluate the antitussive effects of YHN throat spray solution on ammoniainduced cough model in Swiss mice. Swiss mice were induced to cough with a 25% ammonia solution at a 0.5 ml/mouse dose. The latency period of coughing, the number of coughs per minute up to the 5th minute, and the percent inhibition of cough frequency were assessed. The results showed that YHN throat spray solution, administered at 100μl per application once daily and 100 μl per application twice daily, prolonged the latency period of cough onset and significantly reduced the number of coughs compared to the control group. The percent inhibition of cough frequency of YHN throat spray solution at 100μl per application once daily and 100μl per application twice daily were respectively 33.22% and 41.96%. Thus, the YHN throat spray solution exhibited antitussive effects in the ammonia-induced cough model in Swiss mice.

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