Đánh giá kết quả điều trị bệnh vảy nến thông thường bằng bôi potriolac kết hợp uống methotrexat=To evaluate the results of conventional psoriasis treatment with topical potriolac gel combined with oral methotrexate

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Tác giả: Văn Mạnh Hoàng, Công Chính Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y dược lâm sàng 108, 2024

Mô tả vật lý: tr.90-95

Bộ sưu tập: Metadata

ID: 244859

Thêm vào giỏ

Đánh giá kết quả điều trị bệnh vảy nến thông thường bằng bôi potriolac kết hợp uống methotrexate. Đối tượng và phương pháp: Nghiên cứu thử nghiệm lâm sàng có đối chứng so sánh trên 35 bệnh nhân vảy nến mức độ vừa và nặng. Kết quả: Trong nhóm nghiên cứu có 80% bệnh nhân nam và 20% bệnh nhân nữ với độ tuổi trung bình: 56,8 ± 10,5
mức độ bệnh vừa 34%, nặng 66,7%. Tất cả đang ở giai đoạn bệnh hoạt động. Trước điều trị, bệnh nhân mức độ nặng 74,3%, mức độ vừa 25,7%, mức độ nhẹ không có. Sau điều trị bệnh nhân mức độ nhẹ 88,6%, mức độ vừa 11,4%, mức độ nặng không còn. Trước điều trị PASI 24,6 ± 7,3, sau điều trị còn 0,2 ± 0,3 và PASI giảm được 99,01%. Kết quả chung rất tốt 45,7%, tốt 54,3%. Tác dụng khô da gặp 8,6%, rối loạn sắc tố 5,7%, nóng rát/ngứa 8,6%, khác 5,7%. Chi phí điều trị thấp hơn 50% so với thuốc nhập ngoại. Kết luận: Điều trị bệnh vảy nến thể thông thường mức độ vừa và nặng bằng thuốc bôi sản xuất trong nước (potriolac) phối hợp với methotrexat đạt kết quả tương đương thuốc với thuốc nhập ngoại (daivonex). Thuốc ít tác dụng phụ, dễ sử dụng.To evaluate the results of conventional psoriasis treatment with topical Potriolac gel combined with oral methotrexate. Subject and method: It was a comparative controlled clinical trial study on 35 patients with moderate and severe psoriasis. Result: In the study group, there were 80% of male and 20% of female patients, with average age of 56.8 ± 10.5
34% and 66.7% of patients with moderate and severe psoriasis, respectively. All were in active disease stage. Before treatment, patients with severe level, moderate level and mild level were 74.3%, 25.7% and 0%, respectively. After treatment, the patient with mild level, moderate level and severe level were 88.6%, 11.4% and 0%, respectively. Before treatment, PASI score was 24.6 ± 7.3, after treatment it was 0.2 ± 0.3 and PASI score was reduced by 99.01%. Treatment costs was 50% lower than imported drugs. Conclusion: The combination of topical Potriolac gel with methotrexat in the treatment of moderate and severe psoriasis achieved good results. Potriolac gel has few side effects, is easy to use.

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