Thay đổi CRP và procalcitonin trong đợt cấp bệnh phổi tắc nghẽn mạn tính có viêm phổi=Changes of CRP and procalcitonin in exacerbation of chronic obstructive pulmonary disease with pneumonia

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Duy Tuyên Đào, Hữu Song Lê, Đình Tiến Nguyễn, Minh Hải Nguyễn, Xuân Dũng Nguyễn, Văn Luận Phạm, Thị Duyên Thi

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y dược lâm sàng 108, 2024

Mô tả vật lý: tr.1-6

Bộ sưu tập: Báo, Tạp chí

ID: 244863

Thêm vào giỏ

Đánh giá thay đổi nồng độ C-reactive protein (CRP) và procalcitonin (PCT) huyết thanh trong đợt cấp BPTNMT có viêm phổi. Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang trên 138 bệnh nhân (BN) chẩn đoán xác định đợt cấp BPTNMT trong đó có 92 BN đợt cấp có viêm phổi (nhóm bệnh) và 46 BN đợt cấp không có viêm phổi (nhóm chứng). Kết quả: Ở nhóm bệnh nhân BPTNMT đợt cấp có viêm phổi, trung vị nồng độ CRP (51,85 (15,53-136,65) mg/l), PCT (0,23 (0,10-0,69)ng/ml) cao hơn có ý nghĩa so với nhóm không có viêm phổi (7,60 (2,95-27,78) và 0,09 (0,05-0,22)). Tăng CRP ≥ 5mg/l và PCT ≥ 0,25ng/mL chưa thể định hướng khả năng cấy đờm dương tính với vi khuẩn. CRP có giá trị định hướng trong chẩn đoán viêm phổi ở BN đợt cấp BPTNMT với diện tích dưới đường cong ROC là 0,78 (95% KTC: 0,70-0,85), chỉ số Youden là 0,4348, ở điểm cắt CRP 40,8mg/l có độ nhạy 56% và độ đặc hiệu 87%. Kết luận: Nồng độ trung bình CRP và PCT huyết thanh ở nhóm BN đợt cấp BPTNMT có viêm phổi tăng cao hơn rõ rệt so với nhóm không viêm phổi. CRP là dấu ấn sinh học có giá trị định hướng trong chẩn đoán viêm phổi ở bệnh nhân đợt cấp BPTNMT.Research of changes in serum CRP and PCT concentrations during exacerbation of COPD with pneumonia. Subject and method: Cross-sectional study involving 138 patients were diagnosed with exacerbation of COPD, comprising 92 patients were exacerbation of COPD with pneumonia (disease group) and 46 patients were exacerbation of COPD without pneumonia (control group). Result: In the group of patients exacerbation of COPD with pneumonia, the median CRP level (51.85 (15.53-136.65) mg/l), and PCT level (0.23 (0.10-0.69)ng/ml) were significantly higher compared to the group without pneumonia. Increased CRP ≥ 5mg/l and PCT ≥ 0.25ng/mL cannot determine the possibility of sputum culture being positive for bacteria. CRP showed predictive value in diagnosing pneumonia during acute exacerbations of COPD, with an area under the ROC curve of 0.78 (95% CI: 0.70-0.85), a Youden index of 0.4348, and at the CRP cutoff point of 40.8mg/l, achieving a sensitivity of 56% and specificity of 87%. Conclusion: The average serum concentrations of CRP and PCT in the group exacerbation of COPD with pneumonia were significantly higher than group without pneumonia. CRP is a valuable biomarker in diagnosing pneumonia in patients with exacerbations of COPD.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR