Nghiên cứu nồng độ kẽm huyết thanh trên bệnh nhân bạch biến không phân đoạn=Serum zinc level in nonsegmental vitiligo patients

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Tác giả: Thị Thu Hường Triệu, Thế Trung Văn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Da liễu học Việt Nam, 2024

Mô tả vật lý: tr.72-80

Bộ sưu tập: Metadata

ID: 244985

Thêm vào giỏ

The objectives of this study were to determine the difference between the serum zinc levels of patients with nonsegmental vitiligo and those of healthy controls, and to investigate the relationship between serum zinc levels and the clinical characteristics of the patients. Materials and methods: A case-control study was conducted, involving 40 patients with nonsegmental vitiligo and 39 healthy controls matched for age and gender. Vitiligo was diagnosed clinically and confirmed by Wood’s lamp examination. Serum zinc levels of the two groups were measured using a colorimetric assay. Results: The serum zinc level of the nonsegmental vitiligo group was significantly lower than that of the control group (p = 0.048). Specifically, the subgroup of patients with diffuse vitiligo and/or lesion areas larger than 10% of body surface area had markedly lower serum zinc levels compared to healthy individuals (p = 0.006 and p = 0.049, respectively). Conclusions: The findings suggest that low serum zinc levels may be associated with the spread of nonsegmental vitiligo. Therefore, quantification of serum zinc levels should be considered in patients with diffuse type nonsegmental vitiligo and/or skin lesion areas larger than 10% of body surface area.Xác định sự khác biệt giữa nồng độ kẽm huyết thanh của bệnh nhân bạch biến không phân đoạn với người bình thường và mối liên quan với các đặc điểm lâm sàng của bệnh nhân. Đối tượng và phương pháp: Nghiên cứu bệnh - chứng, gồm 40 bệnh nhân bạch biến không phân đoạn và 39 người khỏe mạnh tương đồng về tuổi, giới. Bạch biến được chẩn đoán dựa trên lâm sàng và soi đèn Wood. Huyết thanh của cả hai nhóm đều được đo nồng độ kẽm huyết thanh bằng phương pháp chỉ thị màu. Kết quả: Nồng độ kẽm huyết thanh ở nhóm bệnh thấp hơn nhóm chứng (p = 0,048). Trong đó, nhóm bệnh nhân thể lan tỏa và/hoặc có diện tích tổn thương da trên 10% có nồng độ kẽm huyết thanh thấp hơn so với người khỏe mạnh (p = 0,006 và p = 0,049). Kết luận: Nồng độ kẽm huyết thanh thấp có thể liên quan đến độ lan rộng của bệnh bạch biến không phân đoạn, do đó nên định lượng nồng độ kẽm huyết thanh ở bệnh nhân thể lan tỏa và có diện tích tổn thương da trên 10%.

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