Đánh giá độc tính bán mãn tính của viên nén BOGA - TN ở động vật thí nghiệm=Evaluating the sub-chronic toxicological of the BOGA

Đánh giá độc tính bán mãn tính của viên nén BOGA - TN ở động vật thí nghiệm=Evaluating the sub-chronic toxicological of the BOGA - TN tablets in experimental animals

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Tác giả: Hoang Anh Bui, Pham Ngoc Mai Nguyen, Pham Thu May Nguyen, Thuy Phuong Pham, Vu Lam Trinh

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y dược học cổ truyền Việt Nam, 2024

Mô tả vật lý: tr.75-80

Bộ sưu tập: Metadata

ID: 244991

Thêm vào giỏ

Sub-chronic toxicity experiment was carried out in compliance with the guidance of the World Health Organization. Wistar rats (160 - 200g) of both genders, provided by the Laboratory Animal Center, Dan Phuong district, Hanoi were used. Results: The study was carried out in Wistar rats for 4 consecutive weeks by oral administration at the doses of 0.77 and 2.32g/kg/day. After treatment, no significant treatment-related abnormalities were observed at both doses of Boga-TN, compared to the control group, except for the white blood cells, with lower neutrophil but higher lymphocyte values observed in the treated animals. Histopathology assessment did not show any significant variation between control and treatment groups during the study period. Conclusions: Boga-TN with a dose equivalent to the proposed clinical dose and 3 times the clinical dose did not cause any significant toxicity resulting in death, or produce any hematological, serum chemical alteration, and histo-pathological derangements. However, significant reductions in the levels of WBC, lymphocytes and increased levels of neutrophil in treated groups were detected after 4 weeks of treatment.Thí nghiệm độc tính bán mãn tính được tiến hành theo hướng dẫn của Tổ chức Y tế Thế giới. Chuột Wistar (160 - 200g) cả hai giới, do Trung tâm Động vật thí nghiệm, huyện Đan Phượng, Hà Nội cung cấp. Kết quả: Nghiên cứu được tiến hành trên chuột Wistar trong 4 tuần liên tiếp bằng cách uống liều 0,77 và 2,32g/kg/ngày. Sau khi điều trị, không thấy bất thường đáng kể nào liên quan đến điều trị ở cả hai liều Boga-TN, so với nhóm chứng, ngoại trừ bạch cầu, với bạch cầu trung tính thấp hơn nhưng giá trị tế bào lympho cao hơn được quan sát thấy ở những con vật được điều trị. Đánh giá mô bệnh học không cho thấy bất kỳ sự khác biệt đáng kể nào giữa nhóm chứng và nhóm điều trị trong thời gian nghiên cứu. Kết luận: Boga-TN với liều tương đương với liều lâm sàng đề xuất và gấp 3 lần liều lâm sàng không gây ra bất kỳ độc tính đáng kể nào dẫn đến tử vong hoặc gây ra bất kỳ biến đổi huyết học, hóa học huyết thanh và rối loạn mô bệnh học nào. Tuy nhiên, người ta phát hiện thấy sự giảm đáng kể về lượng bạch cầu, tế bào lympho và tăng lượng bạch cầu trung tính ở nhóm được điều trị sau 4 tuần điều trị.

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