Hoạt tính bảo vệ gan của chiết xuất ethanol quả mai dây (cassia rhombifolia roxb.) chống lại carbon tetrachloride gây tổn thương gan ở chuột=Hepatoprotective activity of ethanol extract from cassia rhombifolia roxb fruit against carbon tetrachloride-induced liver injury in mice

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Tác giả: Thị Phương Nhung Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Khoa học và Công nghệ (ĐH Công nghiệp TP. HCM), 2024

Mô tả vật lý: tr.25-36

Bộ sưu tập: Báo, Tạp chí

ID: 244996

Thêm vào giỏ

Cassia rhombifolia Roxb., a medium-sized woody plant that prefers sunlight, grows rapidly, tolerates drought well, and is widely distributed throughout Vietnam from the delta to the mountainous regions. For a long time, C. rhombifolia has been used by Vietnamese folk medicine as a remedy for constipation, fever, edema, cardiovascular disorders, inflammation and liver damage, excess stomach acid, and other conditions. In current research, the hepatoprotective effects of ethanol extract from C. rhombifolia fruit (EtCR) against carbon tetrachloride-induced liver damage in mice were investigated. Results were compared with those of silymarin, a standard liver-protective drug. It was found that the serum transaminase activity, levels of cytokines causing inflammation, and activity of acid and alkaline phosphatase and antioxidant enzymes in the livers of mice with CCl4 (0.5 mL/kg
ip)-induced liver injury were increased. Treatment with EtCR for 8 weeks prevented these intermediate changes. Histopathological examination also confirmed the liver-protective activity of EtCR when compared to the CCl4 control group. In conclusion, these results indicate that ethanol extract from Cassia rhombifolia fruit (C. rhombifolia) exhibits hepatoprotective effects against carbon tetrachloride-induced liver damage in mice.Cây mai dây (Cassia rhombifolia Roxb.) là cây thân gỗ cỡ vừa, ưa nắng, sinh trưởng nhanh, chịu hạn tốt, phân bố rộng khắp Việt Nam từ đồng bằng đến miền núi. Từ lâu mai dây đã được dân gian Việt Nam sử dụng như là một loại thuốc để chữa táo bón, hạ sốt, phù nề, rối loạn tim mạch, viêm và tổn thương gan, dư thừa axit dạ dày, v.v. Trong nghiên cứu hiện tại, tác dụng bảo vệ gan của chiết xuất ethanol từ quả mai dây (C. rhombifolia, EtCR) đối với tổn thương gan do carbon tetrachloride gây ra đã được nghiên cứu ở chuột. Kết quả được so sánh với kết quả của silymarin, một loại thuốc bảo vệ gan tiêu chuẩn. Người ta nhận thấy rằng có sự gia tăng hoạt động của các transaminase huyết thanh, tăng mức độ các cytokine gây viêm, tăng hoạt tính của axit, phosphatase kiềm, hoạt tính enzyme chống oxy hóa ở gan của những con chuột bị tổn thương gan do CCl4 (0,5 mL/kg
ip) gây ra. Điều trị bằng EtCR trong 8 tuần đã ngăn chặn những thay đổi trung gian này. Kiểm tra mô bệnh học cũng đã xác nhận thêm hoạt động bảo vệ gan của EtCR khi so sánh với chuột đối chứng ở nhóm CCl4. Tóm lại, những kết quả này chỉ ra rằng chiết xuất ethanol của quả mai dây (C. rhombifolia) thể hiện tác dụng bảo vệ gan chống lại tổn thương gan do carbon tetrachloride gây ra ở chuột.

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