Đánh giá tác dụng điều chỉnh rối loạn Lipid máu của cao khô me rừng trên chuột cống trắng=Assessing the dyslipidemia adjusting effects of Phyllanthus emblica L. dry extracts in wistar rats

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Tác giả: Thị Thu Phương Hoàng, Thị Tuyết Nhung Hoàng, Hoàng Ngân Nguyễn, Hoàng Tuấn Nguyễn, Phương Thảo Nguyễn, Đình Sinh Trần, Thị Hạnh Trịnh

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y dược học cổ truyền Việt Nam, 2024

Mô tả vật lý: tr.1-6

Bộ sưu tập: Báo, Tạp chí

ID: 245035

Thêm vào giỏ

The experiment was conducted using the adjusted model of Nassiri et al. (2009). Wistar rats were induced dyslipidemia by giving orally the mixture of cholesterol oil (10 ml/kg/24h dose). Rats were randomly assigned to 5 groups, 10 each (n = 10). Group 1 was given distilled water 10 ml/kg
Group 2 was given cholesterol oil and distilled water 10 ml/ kg after 02 hours, respectively
Group 3 was given cholesterol oil and reagent dose 450 mg/kg after 2 hours
Group 4 was given cholesterol oil + reagent 900 mg/kg after 2 hours
Group 5 was given cholesterol oil + atorvastatin 10 mg/kg after 2 hours. Evaluation indices: triglycerides (TG), total cholesterol, HDL-C, LDL-C blood concentration before the experiments and after 14-28 days. Results: All groups that were induced dyslipidemia with mixture of cholesterol oil 10 ml/kg/24h increased TG, total cholesterol, LDL-C blood concentration. Groups 3, 4, 5 showed the effect of reducing TG, total cholesterol, LDL-C
increased HDL-C blood concentration compared with group 2 at 14 and 28 days after the treatment, the change was statistically significant with p <
0.05. Conclusions: Phyllanthus emblica L. dry extracts at the dose of 450 mg/kg/24h and 900mg/kg/24h showed good effect in the treatment of dyslipidemia, equivalent to Atorvastatin 10mg/kg/24hTheo mô hình của Nassiri và cộng sự (2009), có cải tiến. Chuột cống trắng chủng Wistar được gây rối loạn lipid bằng hỗn hợp dầu cholesterol 10 ml/kg/24h. Chuột được phân ngẫu nhiên vào 5 lô, mỗi lô 10 con (n=10). Lô 1 uống nước cất 10 ml/kg
Lô 2 uống dầu cholesterol + nước cất 10 ml/kg sau 02 giờ
Lô 3 uống dầu cholesterol + thuốc thử 450 mg/kg sau 2 giờ
Lô 4 uống dầu cholesterol + thuốc thử 900 mg/kg sau 2 giờ
Lô 5 uống dầu cholesterol + atorvastatin 10 mg/kg sau 2 giờ. Chỉ tiêu đánh giá: triglycerid (TG), cholesterol toàn phần, HDL-C, LDL-C tại các thời điểm 0, 14 và 28 ngày. Kết quả: Tất cả các lô gây rối loạn lipid bằng dầu cholesterol 10 ml/kg/24h đều gây tăng chỉ số TG, cholesterol toàn phần, LDL-C. Các lô 3, 4, 5 có tác dụng làm giảm các chỉ số TG, cholesterol toàn phần, LDL-C
làm tăng HDL-C trong máu so với lô 2 tại thời điểm 14 và 28 ngày, sự thay đổi có ý nghĩa thống kê với p <
0,05. Kết luận: Cao khô me rừng (Phyllanthus emblica L.) liều 450 mg/kg/24h và liều 900 mg/kg/24h có tác dụng tố

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