Đặc điểm lâm sàng và kết quả điều trị mụn trứng cá mức độ trung bình bằng minocycline uống tại Bệnh viện Da liễu thành phố Cần Thơ năm 2022=The clinical characteristics and the results of the treatment with oral minocycline of moderate acne vulgaris at Can Tho dermato-venereology hospital in 2022

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Tác giả: Nguyễn Ái My Đinh, Thị Kim Ngân Lạc, Thị Thúy Linh Nguyễn, Thị Ngọc Sang Phan, Đặng Quốc Bình Võ, Huỳnh Gia Khang Vương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y dược học Cần Thơ, 2024

Mô tả vật lý: tr.196-202

Bộ sưu tập: Metadata

ID: 245066

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Acne is a chronic skin disease, very common and common in adolescents. The progression of the disease can be self-limiting, but if the disease is not treated or treated incorrectly, it can leave later sequelae. Minocycline has many advantages compared to other antibiotics in the same tetracycline group. However, in Vietnam, there are not many specific studies on treating moderate acne with minocycline. Objectives: To describe the clinical characteristics and evaluate the results of the treatment of moderate acne with oral minocycline. Materials and methods: A descriptive cross-sectional study was conducted on 90 moderate acne vulgaris patients treated with minocycline (oral route). Results: The main distribution of acne lesions accounts for 100%. Papules and whiteheads are the most common (100%). The average GAGs score of acne is 22.98 ± 3.2. The number of inflammatory and non-inflammatory lesions at 8 weeks decreased by 71.6% and 60.7%, respectively, compared to the time of T0. The difference was statistically significant with p<
0.001. GAGs scores decreased significantly after 8 weeks from baseline. The rate of good and excellent response to minocycline treatment after 8 weeks of treatment was 53.4%, and the average response was 46.6%. 8.9% of patients had headaches, 6.7% had cases of dizziness, and 17.8% had digestive disorders. Conclusion: Treatment of moderate acne with minocycline has significantly improved clinical efficacy, especially for inflammatory lesions.Trứng cá là một bệnh da mạn tính, rất phổ biến và thường gặp ở lứa tuổi thanh thiếu niên. Diễn biến của bệnh có thể tự giới hạn, nhưng nếu bệnh không được điều trị hay điều trị không đúng sẽ có thể để lại di chứng về sau. Minocyclin có nhiều ưu điểm so với kháng sinh khác cùng nhóm tetracyclin. Tuy nhiên, tại Việt Nam, điều trị mụn trứng cá mức độ trung bình bằng minocyclin chưa có nhiều nghiên cứu cụ thể. Mục tiêu nghiên cứu: Mô tả đặc điểm lâm sàng và đánh giá kết quả điều trị mụn trứng cá mức độ trung bình bằng minocyclin uống tại Bệnh viện Da liễu thành phố Cần Thơ năm 2022. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang trên 90 bệnh nhân mụn trứng cá mức độ trung bình điều trị bằng minocyclin. Kết quả: Nhóm tuổi từ 18- 24 tuổi (chiếm 52,2%). Nữ chiếm 57,8% và nam chiếm 42,2%. Mặt là vị trí phân bố chủ yếu của sang thương mụn trứng cá chiếm tỉ lệ 100%, 100% bệnh nhân có tổn thương phối hợp. Sang thương sẩn, mụn đầu trắng thường gặp nhiều nhất (100%). Điểm số GAGs trung bình của mụn trứng cá mức độ trung bình là 22,98 ± 3,2. Số lượng thương tổn viêm và không viêm ở thời điểm 8 tuần giảm 71,6% và 60,7% so với thời điểm T0, sự khác biệt có ý nghĩa thống kê với p<
0,001. Điểm số GAGs giảm đáng kể sau 8 tuần so với lúc ban đầu. Tỉ lệ đáp ứng tốt và khá khi điều trị bằng minocyclin sau 8 tuần điều trị là 53,4% và đáp ứng trung bình là 46,6%. 8,9% bệnh nhân có biểu hiện nhức đầu, 6,7% trường hợp chóng mặt và 17,8% rối loạn tiêu hóa. Kết luận: Điều trị mụn trứng cá mức độ trung bình bằng minocyclin đã cải thiện đáng kể hiệu quả lâm sàng, đặc biệt là đối với các thương tổn viêm.

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