Suy giáp thai kỳ ở phụ nữ mang thai 3 tháng đầu tại Trung Tâm Xét Nghiệm Y Khoa Yeslab=Gestational hypothyroidism in pregnant women during first trimester at Yeslab medical test center

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Tác giả: Văn Chương Lê, Minh Tài Nguyễn, Thị Bé Phương Nguyễn, Thị Ngọc Mỹ Nguyễn, Vũ Lam Yên Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y dược học Cần Thơ, 2024

Mô tả vật lý: tr.15-20

Bộ sưu tập: Metadata

ID: 245090

Thêm vào giỏ

Mang thai kết hợp với suy giáp và các rối loạn nội tiết gây hậu quả nghiêm trọng cho mẹ và thai nhi. Tại Việt Nam, tỉ lệ suy giáp trong 3 tháng đầu thai kỳ dao động từ 10,9% đến 16,3%. Suy giáp sớm gây tổn thương não bộ thai nhi và ảnh hưởng phát triển trí tuệ của trẻ. Mục tiêu nghiên cứu: Xác định tỉ lệ suy giáp ở phụ nữ mang thai 3 tháng đầu tại Trung Tâm Xét Nghiệm Y Khoa Yeslab và các yếu tố liên quan. So sánh tỉ lệ suy giáp giữa khoảng tham chiếu của TOSOH và ATA 2017. Đối tượng và phương pháp nghiên cứu: Hồi cứu hồ sơ 119 PNMT 3 tháng đầu khám tại TTXNYK Yeslab từ 9/2022-5/2023 có xét nghiệm TSH. Tỉ lệ suy giáp thai kỳ dựa vào giá trị trung vị TSH ở 2 khoảng tham chiếu: (1) Hãng TOSOH (người châu Á) và (2) ATA 2017 (dành riêng PNMT 3 tháng đầu). Kết quả: Tỉ lệ suy giáp thai kỳ ở PNMT 3 tháng đầu theo TOSOH và ATA 2017 tại TTXNYK Yeslab là 4,2% và 5,9%. So sánh tỉ lệ suy giáp thai kỳ giữa TOSOH và ATA 2017 nhận thấy nhóm PNMT từ 30 tuổi trở lên, tỉ lệ suy giáp theo TOSOH và ATA 2017 là 2,5%, 0,8% và không có sự khác biệt (p>
0,05). Với PNMT dưới 8 tuần tuổi, tỉ lệ suy giáp theo ATA 2017 cao hơn TOSOH (5,0% và 3,4%), khác biệt có ý nghĩa thống kê (p<
0,05). Nồng độ TSH (chỉ số đánh giá tỉ lệ suy giáp thai kỳ) có liên quan với tuổi thai, tuy nhiên không liên quan với tuổi thai phụ. Kết luận: Sử dụng khoảng tham chiếu của ATA 2017 để sàng lọc suy giáp ở PNMT. Nên sàng lọc định kỳ từ sớm để phát hiện bất thường về tuyến giáp và điều trị kịp thời.Pregnancy with endocrine disorders like hypothyroidism can have negative effects on both mother and fetus. In Vietnam, the prevalence of hypothyroidism in the first trimester ranges from 10.9% to 16.3%, resulting in fetal brain damage and potential impact on intellectual development. Objectives: To determine the prevalence of hypothyroidism in pregnant women during the first trimester at Yeslab Medical Testing Center and associated factors. Comparison prevalency of hypothyroidism between the TSH concentration reference range of TOSOH companies and ATA 2017. Materials and methods: Retrospectively reviewed records of 119 pregnant women during first trimester examined at Yeslab Medical Testing Center from September 2022 to May 2023 and had quantitative test results for TSH concentrations. The prevalence of hypothyroidism was determined based on the TSH median in 2 reference ranges: (1) TOSOH company (for Asians) and (2) ATA 2017 guidelines (for first trimester pregnant). Results: Prevalence hypothyroidism according to the two reference ranges TOSOH and ATA 2017 at Yeslab center is 4.2% and 5.9%. Comparing the rate of hypothyroidism in pregnancy between the reference ranges of TOSOH and ATA 2017 recorded in pregnant women aged 30 years and above, the prevalence of hypothyroidism according to TOSOH and ATA 2017 is 2.5%, 0.8% and no difference (p>
0.05). For pregnant women under 8 weeks old, the rate of hypothyroidism according to ATA 2017 is higher than TOSOH (5.0%, 3.4%), the difference is statistically significant (p<
0.05). TSH concentrations are associated with gestational age but not associated with maternal age. Conclusions: The ATA 2017 guidelines can be used when screening for hypothyroidism. Periodic screening should be performed early to detect thyroid abnormalities and receive timely treatment.

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