Nghiên cứu độc tính bán trường diễn và tác dụng chống loét dạ dày của viên nang cứng Khôi tím Bavieco trên chuột cống trắng=Study on the subchronic toxicity and anti-gastric ulcer effect of Khoi tim Bavieco hard capsules on wistar rats

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Tác giả: Văn Hoàng Lê, Thị Hà Nguyễn, Thị Minh Thu Nguyễn, Quốc Sự Phạm, Thanh Tùng Phạm, Thị Yến Quách

Ngôn ngữ: vie

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Thông tin xuất bản: Y dược học cổ truyền Việt Nam, 2024

Mô tả vật lý: tr.59-65

Bộ sưu tập: Metadata

ID: 245124

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Nghiên cứu độc tính bán trường diễn theo quy định của Bộ Y tế Việt Nam vờ tác dụng chống loét dạ dày trên mô hình gây loét dạ dày bỗng indomethacin ờ chuột cống trắng Wistar. Kết quả: Các chuột vẫn hoạt động, đi lại, ăn uống, đại tiểu tiện bình thường. Trọng lượng chuột các lô tăng lên có ý nghĩa thống kê ở ngày 15 và 30 so với ngày 0 (p<
0,001), nhưng không có sự khác biệt giữa lô chứng vờ lô dùng thuốc (p>
0,05). Các chỉ số huyết học, sinh hóa vờ mô học gan, thận của chuột giữa lô chứng vờ lô dùng thuốc và giữa các thời điềm nghiên cứu khác nhau không có ý nghĩa thống kê (p>
0,05). Viên Khôi Tím Bavieco ờ cá hai liều 415,8 mg/kg/ngờy và 1.247,4 mg/kg/ngày X 30 ngày có khả năng làm giảm chỉ số loét, phân trăm ức chế loét và giảm tổn thương trên vi thể dạ dày của chuột. Kết luận: Viên Khôi tím Bavieco với liều uống 415,8 mg/kg/ngày và 1.247,4 mg/kg/ngờy X 30 ngày không gây độc thể trạng, chức năng tạo máu, chức năng gan và thận của chuột, có tác dụng chống loét dạ dày trên mô hình gây loét bâng indomethacin.The subchronic toxicity was studied according to Vietnam Ministry of Health's guidelines while anti-gastric ulcer effect was tested on the model of Wistar rats' gastric ulcers caused by Indomethacin. Results: All rats are still active, walking, eating, urinating normally. The rats' weights increased statistically significantly on days 15 and 30 compared to those of day 0 (p <
0.001), but there were no differences between the control group and treated groups (p>
0,05). The hematological, biochemical and histological indices o f rats between the control group and tested groups and between differentiated study times were not statistically significant (p >
0.05). Khoi Tim capsules at both doses o f 415.8 and 1,247.4 mg/kg/day x 30 days have its ability to reduce ulcer indices, percentages of ulcer inhibition and microscopic damage to rats' stomachs. Conclusions: Khoi Tim Bavieco hard capsules did not show toxicity to the physical conditions, hem atopoietic functions, liver and kidney fu nction s o f experim ental rats and has anti-gastric ulcer effect on the m odel o f gastric ulcer caused by indomethacin.

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