Nghiên cứu đặc điểm lâm sàng, các yếu tố liên quan và so sánh hiệu quả điều trị rụng tóc từng vùng bằng tiêm Betamethasone với bôi Fluocinolone acetonide vào thương tổn tại Bệnh viện Da liễu Thành phố Cần Thơ từ 2022-2023=Studying clinical characteristics and related factors and compare the effectiveness of treatment of regional hair loss using betamethasone injection with application of fluocinolone acetonide injury at Can Tho city dermatology hospital in 2022-2023

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Tác giả: Hoàng Thiên Kim Đào, Vĩnh Đức Hồ, Hồng Hà Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y dược học Cần Thơ, 2024

Mô tả vật lý: tr.82-88

Bộ sưu tập: Metadata

ID: 245130

Thêm vào giỏ

Alopecia areata is an autoimmune condition characterized by sudden hair loss from one or multiple areas on the scalp or body, which can significantly affect the patient's quality of life and have serious psychological implications. Objectives: To investigate the clinical characteristics and associated factors, compare the effectiveness of treatment, and assess the adverse effects in patients with alopecia areata treated with Diprosan® injections (Betamethasone dipropionate and Betamethasone Na phosphate) versus Fluocinolone ointment. Materials and methods: A comparative clinical trial was conducted, using a convenient continuous sampling method, involving 60 diagnosed patients with alopecia areata. Results: The average age is 30.85 ± 8.25, the average disease duration is 10.13 ± 9.71, men predominate with a rate of 62.7%. There was no difference in family history, stress, and exclamation point hair between the mild and severe groups (p>
0.05), but personal history factors were statistically significant (p=0.006). The area distribution of mild injuries is 78.0%, moderate at 16.9%, severe 3.4%, very severe 1.7%. The Fluocinolone topical group had stable treatment results during the two-month treatment period with 80%, after 2 months of stopping and monitoring, the rate was 86.7%. The Betamethasone injection group initially had poorer results, but after 2 months of treatment and follow-up, the results improved with a good rate of 93.1%. Side effects showed that group 1 had itching symptoms, accounting for a fairly high rate of 33.3%, while the remaining had no side effects. Meanwhile, only 17.2% of patients in group 2 had symptoms. Conclusions: Intradermal Betamethasone is a successful treatment option for alopecia areata.Tình trạng rụng tóc từng vùng có đặc điểm là tóc rụng đột ngột từ một hoặc nhiều vùng trên da đầu hoặc cơ thể, có thể gây tác động tâm lý nghiêm trọng ảnh hưởng đáng kể đến chất lượng cuộc sống của bệnh nhân. Mục tiêu nghiên cứu: Khảo sát đặc điểm lâm sàng và các yếu tố liên quan đến mức độ bệnh, so sánh hiệu quả điều trị ở bệnh nhân rụng tóc từng vùng tiêm Diprosan® (Betamethasone dipropionate và Betamethasone Na phosphate) so với thoa Fluocinolone. Đối tượng và phương pháp nghiên cứu: Thử nghiệm lâm sàng đối chứng so sánh, chọn mẫu liên tục thuận tiện, tiến cứu trên 59 bệnh nhân được chẩn đoán rụng tóc từng vùng. Kết quả: Độ tuổi trung bình là 30,85 ± 8,25, thời gian mắc bệnh trung bình là 10,13 ± 9,71, nam giới chiếm ưu thế với tỷ lệ 62,7%. Không có sự khác biệt về tiền sử gia đình, stress, sợi tóc dấu chấm than giữa nhóm nhẹ và nhóm nặng (p>
0,05), nhưng yếu tố tiền sử cá nhân có ý nghĩa thống kê (p=0,006). Phân bố diện tích tổn thương nhẹ chiếm 78,0%, trung bình 16,9%, nặng 3,4%, rất nặng 1,7%. Nhóm thoa Fluocinolone có kết quả điều trị ổn định trong thời gian điều trị trong hai tháng với 80%, sau 2 tháng ngưng và theo dõi ghi nhận tỷ lệ 86,7%. Nhóm tiêm Betamethasone ban đầu nghiên cứu có kết quả kém hơn, nhưng sau từng thời điểm nghiên cứu nhận thấy có sự tích cực. Cụ thể, sau 2 tháng điều trị và theo dõi, kết quả cải thiện với tỷ lệ tốt là 93,1%. Tác dụng phụ cho thấy nhóm 1 có triệu chứng ngứa chiếm tỷ lệ khá cao là 33,3% còn lại là không có tác dụng phụ. Trong khi đó nhóm 2 chỉ có 17,2% bệnh nhân có triệu. Kết luận: Betamethasone tiêm dưới da có hiệu quả trong bệnh rụng tóc từng vùng.

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