Nghiên cứu độc tính cấp và ảnh hưổrng lên nồng độ Interleukin-6 trong huyết thanh của viên hoàn cứng TLT- BCA trên thực nghiệm=Researching the acute toxicity and the effects on Interleukin-6 serum concentrations of the TLT-BCA pill in experiment

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Tác giả: Duy Hoàn Nguyễn, Trưởng Nam Nguyễn, Bá Tuyển Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Y dược học cổ truyền Việt Nam, 2024

Mô tả vật lý: tr.17-23

Bộ sưu tập: Metadata

ID: 245185

Thêm vào giỏ

Acute toxicity evaluation: Swiss rats were orally given the solution o f TLT-BCA p ill with different doses to evaluate toxic dose and LD50 using Litchfield - Wilcoxon method. Effects on Interleukin-6 evaluation: the prostate hyperplasia model in 06 pathological groups were induced by subcutaneously injected testosterone propionate (TP) (0.003g/kg/24h) and the blank group was subcutaneously injected by vegetable oil In 28 consercutive days. Afterward, 04 trial groups were respectively given TLT-BCA (0.7g/kg/day and 2.1g/kg/day), Dutasterlde (25pg/kg/24h) and TamsuIosin 80pg/kg/24h
physiological and pathological groups were respectively given saline orally in 28 consecutive days. Levels of Interleu kin-6 in serum and prostate tissues were collected and compared among 6 groups at the 29th day. Results: The TLT-BCA pill did not show acute toxicity signs and the LD50 was not identified in the highest oral dose of 30.0g/kg/24h. The TLT-BCA pill at the doses of 700mg/kg/24h and 2100mg/kg/24h decreased Interleukin-6 level in serum and prostate issues with p<
0.01 and p<
0.05 respectively. Conclusions: The TLT-BCA pill did not cause acute toxicity and LD50 was not identified. The TLT-BCA pill at the doses of 700mg/kg/24h and 2100mg/kg/24h decreased Interleukin-6 level in serum and prostate issues of laboratory rats.Với độc tính cấp, chuột Swiss được uống viên hoàn cứng TLT-BCA với các liều khác nhau để xác định liều độcvàLD50 theo phương pháp Litchfield - Wilcoxon. VỚI tác dụng lên Interleukin-6, mô hình tăng sản lành tính tuyển tiền liệt ờ 06 lô được gây bổng tiêm dưới da testosterone propionate (TP) liều 0,003g/kg/24h và 01 lô chứng sinh lý tiêm dâu thực vật trong 28 ngày liên tục
04 lô lãn lượt được uống viên hoàn cứng TLT-BCA (0,7g/kg/ngờy và 2,1g/kg/ngày), Dutasteride (25pg/kg/24h) và Tamsulosln 80pg/kg/24h, lô sinh lý và bệnh lý uống nước muối sinh lý liên tục trong 28 ngày. Nông độ Interleukin-6 huyết thanh và mô tuyển tiền liệt được đo lường vờ so sánh giữa các nhóm vào ngày thứ 29. Kết quả: Viên hoàn cứng TLT-BCA chưa biểu hiện độc tính cốp và LD50 chưa được xác định VỚI liều cao nhất là 30,0g/k/24h. với liều 700mg/kg/24h và 2100mg/kg/24h, viên TLT-BCA làm giảm nòng độ Interleukin-6 trong huyết thanh và mô tuyến tiền liệt VỚI p <
0,01 và p <
0,05. Kết luận: Viên hoàn cứng TLT-BCA chưa biểu hiện độc tính cấp và liều LD50 không được xác định. Viên hoàn cứng TLT-BCA liều 700mg/kg/24h và 2100mg/kg/24h làm giám nồng độ Interleukln-6 trong huyết thanh và mô tuyến tiền liệt của chuột.

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