Designing learning activities to develop the ability to apply knowledge and skills learned in teaching is very important and necessary. The content of the article is a document to help teachers of Science subject grade 4 design and implement a number of learning activities that contribute to developing the ability to apply knowledge and skills for students. This article has proposed a number of learning activities in teaching Science subject grade 4 including: practice - experiment activities, problem solving activities in practice, role-playing activities, storytelling.Designing learning activities to develop the ability to apply knowledge and skills learned in teaching is very important and necessary. The content of the article is a document to help teachers of Science subject grade 4 design and implement a number of learning activities that contribute to developing the ability to apply knowledge and skills for students. This article has proposed a number of learning activities in teaching Science subject grade 4 including: practice - experiment activities, problem solving activities in practice, role-playing activities, storytelling.