In the context of digital transformation and the Fourth Industrial Revolution, the application of ChatGPT in scientific research activities at universities is an inevitable trend. ChatGPT has the ability to assist students, lecturers, and researchers in document retrieval, information search, data analysis, and in generating new research ideas. This article examines and proposes several solutions to enhance the effectiveness of ChatGPT applications in scientific research activities at universities.In the context of digital transformation and the Fourth Industrial Revolution, the application of ChatGPT in scientific research activities at universities is an inevitable trend. ChatGPT has the ability to assist students, lecturers, and researchers in document retrieval, information search, data analysis, and in generating new research ideas. This article examines and proposes several solutions to enhance the effectiveness of ChatGPT applications in scientific research activities at universities.