Đánh giá kết quả bước đầu hóa trị metronomic hóa chất UFUR trên bệnh nhân ung thư hạ họng - thanh quản đã được điều trị giai đoạn II-IV=Evaluation of initial results of metronomic chemotherapy with UFUR chemistry in patients with hoprophrophy-larynge cancer has bee n treatment for stages II-IV

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Bích Phương Bùi, Đình Thắng Cao, Thị Bích Ngọc Đặng, Thị Diệp Đào, Thị Vân Lê, Đức Hưng Nguyễn, Quốc Khánh Nguyễn, Thị Phương Anh Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.44-49

Bộ sưu tập: Metadata

ID: 245895

Thêm vào giỏ

Đánh giá kết quả bước đầu hóa trị metronomic Ufur trên bệnh nhân ung thư hạ họng thanh quản tái phát Đối tượng và phương pháp nghiên cứu: 83 bệnh nhân ung thư hạ hong- thanh quản giai đoạn II-IV tái phát được điều trị Ufur duy trì Kết quả: Đa số bệnh gặp ở lứa tuổi 50-70 chiếm 61,4%. Bệnh đa phần gặp ở giai đoạn III,IV, chỉ có 19,2% ở giai đoan II. Tỉ lệ đáp ứng hoàn toàn đạt 28,9%, đáp ứng 1 phần đạt 55,4%, bệnh ổn định đạt 15,6%. Các độc tính ở mức độ cho phép: không có độc tính mức độ 4 trên hệ tạo huyết: giảm HC độ 3(3,6%),Giảm BC độ 3 cos1(1,2%), ... tại thời điểm 1 năm có 6 bệnh nhân tiến triển(7.2%), thời điểm 2 năm là 16 bệnh nhân (19.2%). Số bn có tiến triển tại chỗ, hạch vùng, và di căn xa tại thời điểm năm 1, năm 2 là (6.0%,7.2%,2,4%) và (10.8%,19.2%, 4.8%). Tại thời điểm 1 năm chưa có bn nào tử vong, tại thời điểm năm 2 có 5 bn tử vong chiếm (6.1%). Kết luận: đây là phác đồ tốt mang lại hiệu quả điều trị và tác dụng phụ trong giới hạn cho phép.Evaluate the initial results of Ufur metronomic chemotherapy in patients with recurrent hypopharyngeal cancer. Subjects and research methods: 83 patients with recurrent hypopharyngeal cancer stage II-IV Maintenance Ufur treatment Results: Most diseases occur in the 50-70 age group, accounting for 61.4%. The disease is mostly seen in stages III and IV, with only 19.2% in stage II. The complete response rate reached 28.9%, partial response reached 55.4%, and stable disease reached 15.6%. Toxicity levels at the allowable level: no level 4 toxicity on the hematopoietic system: decreased HC level 3 (3.6%), decreased BC level 3 cos1 (1.2%), ... at the time At 1 year, there were 6 patients with progression (7.2%), at 2 years there were 16 patients (19.2%). The number of patients with local progression, regional lymph nodes, and distant metastasis at year 1 and year 2 were (6.0%, 7.2%, 2.4%) and (10.8%, 19.2%, 4.8%). At 1 year, no patient died, and at year 2, 5 patients died (6.1%). Conclusion: this is a good regimen that provides effective treatment and side effects within allowable limits.

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