Tiềm năng chống viêm khớp của chiết xuất ethanol thô từ quả cọ đuôi cá đối với bệnh viêm khớp dạng thấp do=Anti-arthritic potential of crude extract of fishtail brush fruits on complete freund's adjuvant-induced rheumatoid arthritis in mice

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Tác giả: Thị Phương Nhung Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Khoa học và Công nghệ (ĐH Công nghiệp TP. HCM), 2024

Mô tả vật lý: tr.36-49

Bộ sưu tập: Metadata

ID: 246137

Thêm vào giỏ

Caryota nanas L. là một trong những loại cây trồng phổ biến ở Việt Nam. Người Việt Nam thường sử dụng C. nanas như một vị thuốc cổ truyền để chữa viêm khớp, viêm dạ dày, ghẻ lở, nhọt, hoặc giảm đau tự nhiên. Tuy nhiên, tác dụng chống viêm khớp của chiết xuất quả C. nanas vẫn chưa được khoa học chứng minh hoặc ghi nhận. Nghiên cứu hiện tại đã đánh giá hiệu quả cải thiện của chiết xuất thô của quả Caryota nanas L. (EeCN) (với ba liều khoảng 100, 200 và 300 mg/kg thể trọng) trên mô hình viêm khớp do thuốc bổ trợ hoàn chỉnh của Freund gây ra. Những thay đổi về chu vi và đường kính chân, chỉ số và điểm số viêm khớp, thông số viêm, thay đổi mô học trong mô khớp của các nhóm thí nghiệm đã được ghi nhận. Không giống như nhóm không được điều trị, nhóm được điều trị bằng EeCN cho thấy trọng lượng tương đối của tuyến ức và lách giảm đáng kể (tương ứng là 6,32% và 7,09%), nhiệt độ cơ thể và chân (1,4oC và 1,3oC), chu vi và đường kính chân (10,34 mm và 8,89 mm), chỉ số và điểm viêm khớp (17,25 và 7,87), mức độ bạch cầu, ESR, RF, CRP (2,94 x103tb/mm3, 2,41 mm/giờ, 6,71 mg/L và 6,27 mg/L, tương ứng) (p<
0,001), và tăng đáng kể trọng lượng cơ thể (13,57%), mức hồng cầu (2,96 x106tb/mm3) (p<
0,001). Kiểm tra mô bệnh học cho thấy giảm mạnh tình trạng viêm hoạt dịch và tổn thương sụn, cũng như cải thiện đáng kể không gian khớp. Chiết xuất Ethanol thô của quả Caryota nanas L. (300 mg/kg) có khả năng điều trị viêm khớp
nó có thể là một ứng cử viên đầy hứa hẹn cho việc kiểm soát bệnh viêm khớp.Caryota nanas Lour is one of the most popular plants in Vietnam. Vietnamese people usually use C. nanas as a traditional medicine to treat arthritis, gastritis, scabies, and boils, or natural pain relief. However, the anti-arthritic effect of C. nanas fruit extract has not been scientifically proven or documented yet. The current study evaluated the ameliorative effect of crude extract of Caryota nanas L. fruits (EeCN) (with three doses of about 100, 200, and 300 mg/kg body weight) on the arthritis model induced by Freund's complete adjuvant. The changes in paw circumference and diameter, arthritis index and score, inflammatory parameter, and histological changes in the joint tissue of experimental groups were recorded. Unlike the untreated group, the group treated with EeCN showed a significant decrease in the relative weight of thymus and spleens (6.32% and 7.09%, respectively), body and paw temperature (1.4oC và 1.3oC), paw circumference and diameter (10.34 mm and 8.89 mm), arthritis index and score (17.25 and 7.87), WBCs, ESR, RF, CRP levels (2.94 x103cells/mm3, 2.41 mm/hr, 6.71 mg/L, and 6.27 mg/L, respectively) (p<
0.001), and remarkably increased body weight (13.57%), RBC level (2.96 x106cells/mm3) (p<
0.001). Histopathological examination showed a gross reduction in synovial inflammation and cartilage damage, as well as a significant improvement in joint space. The crude ethanol extract of Caryota nanas L. fruit (300 mg/kg) has the potential for the treatment of arthritis
it could be a promising candidate for the management of arthritis.

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