Although spiritual health is a core dimension of health and wellness, particularly for Latinos, it receives limited attention in health promotion interventions. Examen Tu Salud is a brief intervention for young Latinas in the USA and is designed using culturally tailored spiritual messaging and education provided through daily multimedia messages and weekly remote peer coaching rooted in Ignatian values and pedagogy. Results from this single group intervention study showed that after four weeks, participants reported large increases in spiritual health (Cohen d = 0.82), well-being (Cohen d = 0.91), and happiness (Cohen d = 0.84), and moderate reductions in stress (Cohen d = 0.41) and anxiety (Cohen d = 0.49). These findings further develop the spiritual health intervention literature and establish a baseline for future brief digital health interventions to support Latinas and other groups using culturally tailored spiritual health messaging.