The plant A/T-rich protein and zinc-binding protein (PLATZ) family hasbeen regarded as one of the important plant-specific transcription factors that areinvolved in various biological processes during evolution. Unfortunately, theexpansion of this gene family in cassava (Manihot esculenta) is hardly recognized.This recent work aims to explain the evolution of the MePLATZ gene family by usingvarious bioinformatics tools. Based on the similarity, a total of eight duplicatedMePLATZ genes, including seven duplicated pairs and one pair of three duplicatedgenes have been predicted in the MePLATZ gene family in cassava. Among them,segmental and tandem duplication events were noted to play a crucial role in theexpansion of the MePLATZ gene family. We found that the majority of members ofthe MePLATZ genes contained three or four exons, while at least 10 conserved motifshave been found in the full-length protein sequences. Next, the MePLATZ familycould be categorized into seven different groups similar to those described in thePLATZ family in other higher plant species. Interestingly, the expression levels of17 duplicated MePLATZ genes in leaf samples under drought conditions suggestedthe hypothesis of the functional conservation, redundancy, and divergence thatoccurred in this family. Taken together, our study could provide a foundation to getinsight into the MePLATZ gene family in cassava.The plant A/T-rich protein and zinc-binding protein (PLATZ) family hasbeen regarded as one of the important plant-specific transcription factors that areinvolved in various biological processes during evolution. Unfortunately, theexpansion of this gene family in cassava (Manihot esculenta) is hardly recognized.This recent work aims to explain the evolution of the MePLATZ gene family by usingvarious bioinformatics tools. Based on the similarity, a total of eight duplicatedMePLATZ genes, including seven duplicated pairs and one pair of three duplicatedgenes have been predicted in the MePLATZ gene family in cassava. Among them,segmental and tandem duplication events were noted to play a crucial role in theexpansion of the MePLATZ gene family. We found that the majority of members ofthe MePLATZ genes contained three or four exons, while at least 10 conserved motifshave been found in the full-length protein sequences. Next, the MePLATZ familycould be categorized into seven different groups similar to those described in thePLATZ family in other higher plant species. Interestingly, the expression levels of17 duplicated MePLATZ genes in leaf samples under drought conditions suggestedthe hypothesis of the functional conservation, redundancy, and divergence thatoccurred in this family. Taken together, our study could provide a foundation to getinsight into the MePLATZ gene family in cassava.