Self-Assembled Molecules - New Kind of Protein Ligands: Supramolecular Ligands

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Tác giả: Irena Roterman, Leszek Konieczny

Ngôn ngữ: eng

ISBN-13: 978-3319656380

Ký hiệu phân loại:

Thông tin xuất bản: Cham, Switzerland : Springer Nature, 2017

Mô tả vật lý: 1 electronic resource (136 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 248086

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but "naturally irreversible" complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book.
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