Ảnh hưởng của phương pháp bào chế đến tác dụng an thần của Viễn chí trên thực nghiệm=Effect of processing methods of Radix Polygalae on its sedative effects in experiment.

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Tác giả: Đức Khải Danh, Bích Ngọc Giàu Lư, Thị Phương Thùy Nguyễn, Thị Hiệp Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2024

Mô tả vật lý: tr.160

Bộ sưu tập: Metadata

ID: 249353

Thêm vào giỏ

Radix polygalae has sedative, cognitive-enhancing, phlegm-dispelling, and detoxifying effects. However, its raw form may lead to gastric irritation and intestinal damage. Over time, R. polygalae has been processed using various methods to reduce toxicity and enhance therapeutic efficacy. According to the guidelines of the Ministry of Health of Viet Nam, R. polygalae is processed using two methods: bran-frying and licorice-frying. This study evaluated the effects of processing methods, as guided by the Ministry of Health, on the sedative effects of R. polygalae in experimental models. The sedative effects were assessed using the light-dark box and rotarod tests. The results showed that raw R. polygalae showed no sedative effects at the tested dose. The aqueous extracts of bran-fried and licorice-fried R. polygalae exhibited sedative effects at the same oral dose of 2.88 g of herb/kg. Both processing methods demonstrated comparable effects in the tested models. The enhanced sedative effects may be related to increased levels of saponins and tenuifolin after processing. Therefore, the processing methods significantly affect the sedative properties of R. polygalae. These findings provide evidence to optimize the clinical application of processed R. polygalae in anxiety management.Viễn chí có tác dụng an thần ích trí, hóa đàm, chỉ khái, giải độc, nhưng khi dùng sống có thể gây kích ứng dạ dày và tổn thương đường ruột. Để giảm độc tính và tăng hiệu quả điều trị, Viễn chí được bào chế bằng nhiều phương pháp, trong đó Bộ Y tế Việt Nam hướng dẫn hai phương pháp là Viễn chí sao cám và Viễn chí chích cam thảo. Trong nghiên cứu này, tác dụng an thần được đánh giá bằng mô hình sáng tối và rotarod. Kết quả cho thấy Viễn chí phiến không thể hiện tác dụng an thần ở liều thử nghiệm. Viễn chí sao cám và Viễn chí chích cam thảo đều thể hiện tác dụng an thần ở liều uống 2,88 g dược liệu/kg. Viễn chí sao cám có tác dụng an thần tương đương với Viễn chí chích cam thảo trong các mô hình thử nghiệm. Sự gia tăng hiệu quả an thần có thể liên quan đến việc tăng hàm lượng saponin và tenuifolin sau khi chế biến. Như vậy, các phương pháp bào chế có ảnh hưởng đáng kể đến tác dụng an thần của Viễn chí. Những phát hiện này cung cấp bằng chứng để tối ưu hóa việc sử dụng Viễn chí trong lâm sàng.

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