The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr

• Tác giả: Mélanie Lambert, Géraldine Miquel, Eric Thorin, Nathalie Thorin-Trescases, Louis Villeneuve
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.042 Genetic diseases (Hereditary diseases)
• Thông tin xuất bản: Switzerland : GeroScience , 2025
• Bộ sưu tập: NCBI
• ID: 249775

Tóm tắt

Accumulation of cerebral senescent cells may compromise the continuum between vascular and neuronal function, leading to damage and cognitive decline. Elimination of senescent cells might therefore preserve vascular and neuronal functions. To test this hypothesis, we used male and female atherosclerotic LDLr