BACKGROUND: Retroperitoneal schwannomas are rare. The purpose of this study was to present our experience with the diagnosis and treatment of 67 such tumors. METHODS: We retrospectively analyzed 67 patients with retroperitoneal schwannoma admitted to the Peking University International Hospital from 2015 to 2021. RESULTS: Thirty-seven of the 67 patients had no obvious clinical symptoms. Complete excision was obtained in 62 and subtotal excision in 5 cases. In7 cases, tumor resection was combined with organ resection. The intraoperative blood loss was 300 ml (20-9,000 ml), the maximum size of the tumor was 9 cm (2.5-26 cm), and postoperative complication occurred in six cases (9.0%). Compared with abdominal retroperitoneal tumors, pelvic retroperitoneal tumors had larger tumor volume, more bleeding, higher proportion of block resection, and longer postoperative hospitalization time ( CONCLUSION: Complete resection of a retroperitoneal schwannoma can achieve a good long-term prognosis. Residual tumor after surgery progresses slowly and rarely become malignant. We recommend early resection after the discovery of a pelvic retroperitoneal schwannoma.