Most major bleeds in preterm infants occur in the absence of severe thrombocytopenia: an observational cohort study.

• Tác giả: Camila Caram-Deelder, Linda S de Vries, Karin Fijnvandraat, Suzanne F Fustolo-Gunnink, Nadine M A Hooiveld, Enrico Lopriore, Sylke J Steggerda, Johanna G van der Bom, Hilde van der Staaij
• Ngôn ngữ: eng
• Ký hiệu phân loại: 780.904 1900—1999
• Thông tin xuất bản: England : Archives of disease in childhood. Fetal and neonatal edition , 2025
• Bộ sưu tập: NCBI
• ID: 250787

Tóm tắt

 OBJECTIVE: To describe the incidence of major bleeds according to different platelet counts in very preterm infants, and to explore whether this association is influenced by other risk factors for bleeding. DESIGN: Observational cohort study. SETTING: A Dutch tertiary care neonatal intensive care unit. PATIENTS: All consecutive infants with a gestational age at birth <
 32 weeks admitted between January 2004 and July 2022. EXPOSURE: Infants were stratified into nine groups based on their nadir platelet count (×10 MAIN OUTCOME MEASURE: Incidence of major bleeds during admission. Logistic regression analysis was used to quantify the relationship between nadir platelet count and incidence of major bleeds. RESULTS: Among 2772 included infants, 224 (8%) developed a major bleed. Of the infants with a major bleed, 92% (206/224) had a nadir platelet count ≥50×10 CONCLUSION: In very preterm infants, the vast majority of major bleeds occur in infants without severe thrombocytopenia.