Increased peripheral leukocyte aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis: A study based on clinical evidence.

• Tác giả: Reziya Abuduxukuer, Zhi-Bo Chen, Jian-Hua Gao, Zhen-Ni Guo, Ying He, Yan Jia, Li-Gang Jiang, Yongfei Jiang, Hui-Min Jin, Chun-Ying Li, Guang-Cai Li, Song Li, Liang Liu, Xiao-Dong Liu, Xiu-Ping Liu, Thanh N Nguyen, Yingbin Qi, Yang Qu, Rui-Hong Teng, Jun-Min Wang, Yi Yang, Bai-Jing Zhang, Ke-Jia Zhang, Peng Zhang, Xian-Kun Zhang, Yu Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 691.99 Adhesives and sealants
• Thông tin xuất bản: United States : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 251124

Tóm tắt

Whether the dynamic development of peripheral inflammation aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis (IVT), remains unclear and warrants further study. In this study, total of 1034 patients with acute ischemic stroke who underwent IVT were enrolled. Serum leukocyte variation (whether increase from baseline to 24 h after IVT), National Institutes of Health Stroke Scale (NIHSS), infarct volume, early neurologic deterioration (END), the unfavorable outcome at 3-month (modified Rankin Scale [mRS] score ≥3) and mortality were recorded. Serum brain injury biomarkers, including Glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1), S100