Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis.

• Tác giả: Shmulik Avlas, Natalie Davidian, Anish Dsilva, Yaara Gordon, Kevin S Gorski, Michal Itan, Ariel Munitz, Jane R Parnes, Elizaveta Razravina, Natalie Rhone, Marc E Rothenberg, Shraddha Sharma, Joseph D Sherrill, Chen Varol, Ariel Wagner, Israel Zan-Bar, Steven F Ziegler
• Ngôn ngữ: eng
• Ký hiệu phân loại: 978.02 1800–1899
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 251212

Tóm tắt

RATIONALE: Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE and whether their activities are distinct requires further investigation. METHODS: Experimental EoE was induced in wild type (WT) RESULTS: TSLP and IL-33 were overexpressed in human and experimental EoE. Human and mouse esophageal MCs displayed the highest level of CONCLUSION: TSLP and IL-33 have non-redundant functions in experimental EoE. This study highlights TSLP as an upstream regulator of IL-13 and a potential therapeutic target for EoE.