Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior.

• Tác giả: Peter D Balsam, Meghan E Gallo, Christoph Kellendonk, Sinead Moyles, Pedro R Olivetti, Ricardo Raudales, MaryElena Sumerau, Arturo Torres-Herraez
• Ngôn ngữ: eng
• Ký hiệu phân loại: 912.01 Philosophy and theory
• Thông tin xuất bản: England : Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 251365

Tóm tắt

Schizophrenia is a neuropsychiatric disorder with postulated neurodevelopmental etiology. Genetic and imaging studies have shown enhanced dopamine and D2 receptor occupancy in the striatum of patients with schizophrenia. However, whether alterations in postnatal striatal dopamine can lead to long-lasting changes in brain function and behavior is still unclear. Here, we approximated striatal D2R hyperfunction in mice via designer receptor-mediated activation of inhibitory Gi-protein signaling during a defined postnatal time window. We found that G