Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop.

• Tác giả: Xian-Hui Dong, Shun-Kang Dou, Wei-Jie Du, Chuan-Hao Huang, Min Huang, Ying-Qiong Jia, Jian-Hao Jiang, Tian-Tian Ju, Na Li, Wan-Hong Li, Ying Li, Kui-Wu Liu, Ying-Qi Liu, Mei-Xi Lu, Zhong-Ting Mei, Xiao-Chen Pang, Zhe-Zhe Qu, Zhi-Yong Sun, Chang-Hao Wang, Fan Wu, Bao-Feng Yang, Shu-Ting Yu, Yao-Zhi Zhang, Yi Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: United States : Acta pharmacologica Sinica , 2025
• Bộ sưu tập: NCBI
• ID: 251565

Tóm tắt

The N7-methylguanosine (m7G) methyltransferase Mettl1 has been recently implicated in cardiac repair and fibrosis. In this study we investigated the role of Mettl1 in mouse cardiomyocytes injury and the underlying mechanisms. Cardiac ischemia/reperfusion (I/R) I/R model was established in mice by ligation of the left anterior descending coronary artery (LAD) for 45 min followed by reperfusion for 24 h. We showed the mRNA and protein levels of Mettl1 were significantly upregulated in mouse I/R hearts and H