HIV DNA Levels in Persons Who Acquired HIV in the Setting of Long-Acting Cabotegravir for HIV Prevention: Analysis of Cases from HPTN 083 and 084.

• Tác giả: Myron S Cohen, Sinead Delany-Moretlwe, Susan H Eshleman, Jennifer Farrior, Jessica M Fogel, Beatriz Grinsztejn, Xu Guo, Brett Hanscom, Mina C Hosseinipour, Raphael J Landovitz, Mark A Marzinke, Carrie-Anne Mathew, Marybeth McCauley, Juliet Mpendo, Deborah Persaud, Estelle Piwowar-Manning, Paul Richardson, Alex R Rinehart, James F Rooney, Joseph Szewczyk, Ha Viet Tran, Chaiwat Ungsedhapand, Zhe Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 003.209 Historical, geographic, persons treatment of forecasting as a discipline
• Thông tin xuất bản: United States : AIDS research and human retroviruses , 2025
• Bộ sưu tập: NCBI
• ID: 251690

Tóm tắt

 We evaluated HIV DNA levels in individuals who received long-acting cabotegravir (CAB-LA) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) pre-exposure prophylaxis in the HPTN 083 and 084 trials and had HIV DNA testing performed to help determine HIV status. HIV DNA testing was performed using peripheral blood mononuclear cell (PBMC) samples collected after a reactive HIV test was obtained at a study site. DNA was quantified using droplet digital PCR (lower limit of detection [LLOD]: 4.09 copies/million PBMCs). Final HIV status and the timing of the first HIV-positive visit were determined by an independent adjudication committee based on HIV test results from real-time site testing and retrospective testing at a centralized laboratory. HIV DNA testing was performed for 133 participants [21 HIV-positive (7 CAB-LA arm, 14 TDF/FTC arm) and 112 HIV-negative
  1-6 tests/person]. For persons with HIV, the time between the first HIV-positive visit and collection of the first sample for DNA testing was a median of 81 days for those receiving CAB-LA (range 41-246) and 11 days for those receiving TDF/FTC (range 3-127). Four (57.1%) of the seven CAB-LA cases with infection had a low initial DNA result [three detected <
 LLOD
  one near the LLOD (4.2 copies/10