Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers.

• Tác giả: Ayinazhaer Aihemaiti, Fu Fan, Miao-Miao Gong, Hui-Min Lei, Yu-Qing Liu, Ying Shen, Ya-Bin Tang, Rui-Xue Xia, Jun-Ting Xie, Bin-Bing S Zhou, Liang Zhu, Pei-Chen Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 287.533 *Independent Methodists
• Thông tin xuất bản: United States : Acta pharmacologica Sinica , 2025
• Bộ sưu tập: NCBI
• ID: 251828

Tóm tắt

RAS is the most frequently mutated oncoprotein for cancer driving. Understanding of RAS biology and discovery of druggable lynchpins in RAS pathway is a prerequisite for targeted therapy of RAS-mutant cancers. The recent identification of KRAS