Embryonic Lethal Abnormal Visual-Like Protein 1 Aggravates Caerulein-Induced AR42J Cell Injury and Macrophage M1 Polarization to Accelerate Acute Pancreatitis by Upregulating TRAF6.

• Tác giả: Yue Sun, Xin Wang, Bin Yan, Wenyong Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 398.352 Persons without paranormal powers
• Thông tin xuất bản: United States : Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research , 2025
• Bộ sưu tập: NCBI
• ID: 251896

Tóm tắt

Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been found to promote the progression of acute pancreatitis (AP). However, its underlying molecular mechanisms in AP need to be further revealed. Caerulein-induced AR42J cells were used to construct AP cell models. Cell viability and apoptosis were measured by Cell Counting Kit 8 assay and flow cytometry. Levels of inflammatory factors and oxidative stress-related markers were assessed. The medium of AR42J cells was collected for coculturing RAW264.7 cells. Macrophage marker CD86