Our paper was conducted to certify the role of employee well-being, job satisfaction, and post-Covid-19 syndrome in the job performance of employees working at Linh Trung Export Processing Zone in Ho Chi Minh City. Based on previous theoretical and empirical studies, we constructed the research conceptual framework and hypotheses. We applied a convenience sample method and conducted a direct survey with 439 respondents who suffer from post-Covid-19 symptoms. SPSS 25 software and AMOS 24 software were used to test hypotheses. The results illustrated that employee well-being and job satisfaction had a positive and strong relationship with employee performance, while post-Covid-19 syndrome strongly and negatively impacted employee performance. Moreover, the factors affecting employee performance in descending order were employee well-being, job satisfaction, and post-Covid-19 syndrome. Finally, we showed some theoretical and practical contributions to enhancing the level of performance of employees working at Linh Trung Export Processing Zone in Ho Chi Minh City as well as at other companies in Vietnam suffering from post-Covid-19 syndrome.Our paper was conducted to certify the role of employee well-being, job satisfaction, and post-Covid-19 syndrome in the job performance of employees working at Linh Trung Export Processing Zone in Ho Chi Minh City. Based on previous theoretical and empirical studies, we constructed the research conceptual framework and hypotheses. We applied a convenience sample method and conducted a direct survey with 439 respondents who suffer from post-Covid-19 symptoms. SPSS 25 software and AMOS 24 software were used to test hypotheses. The results illustrated that employee well-being and job satisfaction had a positive and strong relationship with employee performance, while post-Covid-19 syndrome strongly and negatively impacted employee performance. Moreover, the factors affecting employee performance in descending order were employee well-being, job satisfaction, and post-Covid-19 syndrome. Finally, we showed some theoretical and practical contributions to enhancing the level of performance of employees working at Linh Trung Export Processing Zone in Ho Chi Minh City as well as at other companies in Vietnam suffering from post-Covid-19 syndrome.