CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients.

• Tác giả: Jan E Azarov, Josef Kautzner, Lukas Kryze, Jan Kukla, Lucie Necasova, Ksenia Sedova, Marek Sramko, Peter M Van Dam
• Ngôn ngữ: eng
• Ký hiệu phân loại: 152.158 Localization
• Thông tin xuất bản: United States : Journal of cardiovascular electrophysiology , 2025
• Bộ sưu tập: NCBI
• ID: 252449

Tóm tắt

 INTRODUCTION: A variable proportion of non-responders to cardiac resynchronization therapy (CRT) warrants the search for new approaches to optimize the position of the left ventricular (LV) lead and the CRT device programming. CineECG is a novel ECG modality proposed for the spatial visualization and quantification of myocardial depolarization and repolarization sequences. OBJECTIVE: The present study aimed to evaluate CineECG-derived parameters in different pacing modes and to test their associations with acute hemodynamic responses in CRT patients. METHODS AND RESULTS: CineECG was used to construct the average electrical path within the cardiac anatomy from the 12-lead ECG. CineECG and LV dP/dt max were tested in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block (QRS: 170 ± 17 ms
  LVEF: 26 ± 5.5%) under pacing protocols with different LV lead localizations. The CineECG-derived path directions were computed for the QRS and ST-T intervals for the anteroposterior (X CONCLUSION: The acute hemodynamic response in CRT patients was associated with specific CineECG repolarization sequence parameters, warranting their further testing as potential predictors of clinical outcomes.