Radiopharmaceutical formulation and preliminary clinical dosimetry of [

• Tác giả: Clemens Decristoforo, Gianpaolo di Santo, Leonhard Gruber, Anton Amadeus Hörmann, Lieke Joosten, Mark Konijnenberg, Martin Kraihammer, Ariane Kronthaler, Peter Laverman, Christian Mair, Irene Virgolini, Elisabeth von Guggenberg, Taraneh Sadat Zavvar
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.759 *Full-text database management systems
• Thông tin xuất bản: Germany : European journal of nuclear medicine and molecular imaging , 2025
• Bộ sưu tập: NCBI
• ID: 252627

Tóm tắt

PURPOSE: Radiolabelled minigastrin (MG) analogues targeting the cholecystokinin-2 receptor (CCK2R) have proven to be a promising approach for peptide receptor radionuclide therapy (PRRT). In this study, we report on the radiopharmaceutical development and standardization of the preparation of [ METHODS: Five individual batches of [ RESULTS: The automated cassette-based production of [ CONCLUSION: The radiopharmaceutical development and the preclinical/clinical results support the initiation of a first clinical trial to evaluate the therapeutic potential of [