Đánh giá đặc điểm chất lượng mô dây rốn thu thập tại Bệnh viện Bưu Điện=Evaluation of quality characteristics of collected umbilical cord tissue at Buu Dien hospital

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hoàng Việt Nguyễn, Hồng Trường Nguyễn, Minh Đức Nguyễn, Văn Hoàng Nguyễn, Văn Long Nguyễn, Hồng Hà Phạm, Trần Thanh Quý Phan, Thị Hà Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.322-326

Bộ sưu tập: Metadata

ID: 252656

Thêm vào giỏ

Mô dây rốn là nguồn cung cấp tế bào gốc trung mô tiềm năng cho y học tái tạo và điều trị trong hàng thập kỷ qua. Tuy nhiên quá trình thu thập mô dây rốn luôn có nguy cơ về chất lượng mẫu không đảm bảo và có tỷ lệ nhiễm nấm và vi khuẩn ảnh hưởng tới quá trình bảo quản và điều trị sau này. Nghiên cứu được tiến hành nhằm đánh giá chất lượng ban đầu của mô dây rốn thu thập và đánh giá vai trò của một số yếu tố liên quan với kết quả thu thập mô dây rốn. Nghiên cứu mô tả cắt ngang trên 126 mẫu mô dây rốn được thu thập tại Trung tâm Tế bào gốc và Di truyền, Bệnh viện Bưu Điện từ tháng 04 năm 2023 đến tháng 4 năm 2024. Kết quả cho thấy tỷ lệ mô dây rốn từ trẻ trai cao hơn so với trẻ gái (65,1% và 34,9%). Đa số các trẻ sinh ở lần thứ hai được lưu mô cuống rốn (71,6%). Độ tuổi trung bình của các sản phụ lưu trữ mô dây rốn là 32,9 ± 5,8 tuổi. Tuổi của thai nhi khi sinh trung bình là 38,2 ± 1,2 tuần cao nhất ở nhóm 37 - 38 tuần chiếm 51,3%. Xét nghiệm vi sinh ghi nhận 1 mẫu dương tính với vi khuẩn và nấm chiếm tỷ lệ 0,8%. Toàn bộ số mẫu đều có màu sắc, độ tươi, kích thước và hình dạng đạt tiêu chuẩn.Umbilical cord tissue has been a potential source of mesenchymal stem cells for regenerative medicine and therapy for decades. However, the process of collecting umbilical cord tissue always has the risk of poor sample quality and the incidence of fungal and bacterial infections that can affect the preservation and future treatment process. This study was conducted to evaluate the initial quality of umbilical cord tissue collected and finding the role of the factors and the results in collected umbilical cord tissue. A cross-sectional descriptive study on 126 umbilical cord tissue samples collected for autologous purposes at Stem cell and Genetic Center, Buu Dien Hospital from April 2023 to April 2024. Results showed that the proportion of boys is higher than girls (65.1% and 34.9%). The majority of second-born babies had umbilical cord tissue saved (71.6%). The average age of pregnant women with umbilical cord tissue saved was 32.9 ± 5.8 years old. The average age of the fetus at birth is 38.2 ± 1.2 weeks, highest in the 37 - 38 weeks group, is about 51.3%. Microbiological testing showed 1 sample positive with bacteria and fungi with the proportion is 0.8%. All samples have standard color, freshness, size and shape.

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