Terahertz scanning near-field optical microscopy for biomedical detection: Recent advances, challenges, and future perspectives.

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Tác giả: Ligang Chen, Guanyin Cheng, Junchao Fan, Ying Fu, Yuansen Guo, Jiaguang Han, Fucheng Qiu, Fei Sun, Yiwen Sun, Huabin Wang, Tianwu Wang, Xunbin Wei, Jonathan J Wilksch, Shixiang Xu, Shihan Yan, Zhongbo Yang

Ngôn ngữ: eng

Ký hiệu phân loại: 001.44 Support of and incentives for research

Thông tin xuất bản: England : Biotechnology advances , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 253057

Terahertz (THz) radiation is widely recognized as a non-destructive, label-free, and highly- sensitive tool for biomedical detections. Nevertheless, its application in precision biomedical fields faces challenges due to poor spatial resolution caused by intrinsically long wavelength characteristics. THz scanning near-field optical microscopy (THz-SNOM), which surpasses the Rayleigh criterion, offers micrometer and nanometer-scale spatial resolution, making it possible to perform precise bioinspection with THz imaging. THz-SNOM is attracting considerable attention for its potential in advanced biomedical research and diagnosis. Currently, its family typically includes four members based on distinct principles, which are suitable for different biological applications. This review provides an overview of the principles of these THz-SNOM modalities, outlines their various applications, identifies the obstacles hindering their performance, and envisions their future development.
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