The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial.

• Tác giả: Duvuru Geetha, Carmel Hawley, David R W Jayne, Andreas Kronbichler, Mark A Little, Peter A Merkel, Eri Muso, Balazs Odler, Charles D Pusey, Regina Riedl, Wladimir M Szpirt, Vladimir Tesar, Lisa Uchida, Zachary S Wallace, Michael Walsh, Giles Walters
• Ngôn ngữ: eng
• Ký hiệu phân loại: 363.737 Measures to prevent, protect against, limit effects of pollution
• Thông tin xuất bản: United States : Kidney international , 2025
• Bộ sưu tập: NCBI
• ID: 253077

Tóm tắt

Therapeutic plasma exchange (PLEX) is an adjunctive treatment for patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and kidney involvement. Little is known about the effect of PLEX on early changes in kidney function. This post-hoc analysis of the PEXIVAS trial investigated the effects of PLEX on changes in kidney function within 12 months. PEXIVAS was a randomized controlled trial recruiting 691 patients with ANCA-associated glomerulonephritis, of whom 349 underwent PLEX and 342 received no-PLEX. The primary outcomes of this post hoc study of PEXIVAS were change in estimated glomerular filtration rate (eGFR) from baseline and recovery of kidney function (defined as eGFR increase of 15ml/min/1.73m